Just shared at Keystone Symposia a new @ArcInstitute discovery of the bridge RNA recombinase mechanism: a new class of natural RNA-guided systems that retains the key property of programmability from RNAi and CRISPR while enabling large-scale genome design beyond RNA and DNA cuts

Our Ashley Reid spotted in the The New York Times 😁

⏳ REGISTER⌛️ before you miss out, for 4 days of talks from top immunologists on the latest cancer immunotherapy strategies, featuring Tak Mak, @miriammerad Jon Kagan Eric Vivier and TurleyLab ! Sign up for the 9th International Immunoschool here: eventbrite.com/e/internationa…

Impressive potency of chemo-free #immunotherapy as 1st-line treatment for #lymphoma with 85% complete remission rate... w thanks to the patients, families, and clinical research team Mount Sinai Health System and around the world. bit.ly/3RFW4oO

Pleased to share our latest work from Miriam Merad, MD, PhD lab Lipschultz Precision Immunology Institute, where we try to address the Q: Do tumors alter the epigenetic state of myeloid progenitors in marrow, and are certain aspects of immunosuppressive mono-macrophage fate sealed before they enter the tumor?🧵

Complete substitution with modified nucleotides in self-amplifying RNA suppresses the interferon response and increases potency go.nature.com/3RYbPHK

If complete modified nt substitution abrogates IFN-I responses and is compatible with RdRp, why haven't we found viruses exploiting this as escape strategy?

Science Magazine Miriam Merad, MD, PhD How does immune aging affect our ❤️🩸cardiovascular system and beyond, and how can we protect ourselves? Find some of the answers in an essay by Fil Swirski & Scientists Cameron McAlpine and Nicolas Vabret, starting on page 5 >>> science.org/content/resour…

Online immunology education for a global world dlvr.it/T9WTG8

Competition between two HUSH complexes orchestrates the immune response to retroelement invasion cell.com/molecular-cell…

While all of our body’s systems deteriorate over time, #ImmuneSystemaging has a particular impact on the health of our #CardiovascularSystem. Learn More from Cameron McAlpine, Nicolas Vabret & Fil Swirski & Scientists in @sciencemagazine's Frontiers of Medical Research: Immunology: science.org/do/10.1126/sci…

JOIN US Oct 3 in NY for: Next Generation Immunotherapy Discoveries, a symposium on innate immunology & more, organized by Eric Vivier Innate Pharma Miriam Merad, MD, PhD, with lunch & cocktail reception. Limited spaces available. Don’t miss out! REGISTER FOR FREE innate-symposium.com

Adaptive immunity to retroelements promotes barrier integrity biorxiv.org/cgi/content/sh… #biorxiv_immuno

📜#INFLAMMAGING STUDY📜Aging is the main risk factor for cancer. In Science Magazine, Matthew D. Park, Ph.D. & Miriam Merad, MD, PhD describe how an aging hematopoietic system fuels myeloid dysfunction and inhibits control of lung tumors, raising new treatment options 👇 science.org/doi/10.1126/sc…

Hub#1 is back TODAY 🥳 we will start with Arthur Mortha Arthur Mortha from UofT Immunology , who will present a #preprint by @BecherLab and Sarah Mundt labs about the role of monocyte-derived cells in oxidative tissue damage in neuroinflammation 🤯💥🩹 👇 biorxiv.org/content/10.110…

#Hub1 will follow with Laura Rosenberg from Lipschultz Precision Immunology Institute who will present a #preprint by Andy Minn lab about how targeting interferon can prevent epigenetic evolution and resistance to cancer immunotherapies 🎯💉🧬 👇 biorxiv.org/content/10.110…

👻🎃 Shoutout to my amazing PhD students for dressing up as their -not- favorite lab techniques. Happy Halloween!

Exposure to sugar rationing in the first 1000 days of life protected against chronic disease | Science science.org/doi/10.1126/sc…

Registration is now open for the next ImmunoSchool! This year’s theme: "10 Years of Discovery in Immunotherapy." We’ve put together a stellar lineup of speakers—don’t miss it! Free registration @ bit.ly/3WFj0Hc #ImmunoSchool #Immunotherapy #CancerResearch

T cells do the heavy lifting when it comes to the anti-tumor action of checkpoint immunotherapy. But do antibodies play a role too? That’s the question @yile_dai looked to answer in his thesis work, out today in nature! 🧵below nature.com/articles/s4158…