New paper from the Shaw lab- star postdoc Nazma Malik bookends a series of papers from our lab over the last 12 years Induction of lysosomal and mitochondrial biogenesis by AMPK phosphorylation of FNIP1 science.org/doi/10.1126/sc…

10 more women in STEM -pick it up and keep it moving Jenny Visser Kristy A. Brown Lila Allou Nazma Malik Dagmar Scheel-Toelln Kendle Maslowski Lab Sarah Dimeloe ildem akerman Cecilia Lindgren Alice Williamson

An exciting week MRC Laboratory of Medical Sciences (MRC LMS) with the official opening by HRH The Princess Royal, a longstanding champion of #Science and #WomeninSTEM - our new building's design supports our transdisciplinary team science strategy with impact on human health - more here: lms.mrc.ac.uk/opening-of-mrc…

Acetyl-CoA carboxylase obstructs CD8+ T cell lipid utilization in the tumor microenvironment Cell Metabolism Thaxton Lab cell.com/cell-metabolis…

These remarkable results from our own Stuart Cook may hold the key to healthier, longer lives. Read our news story here lms.mrc.ac.uk/scientists-fin… and on BBC News (UK) bbc.co.uk/news/articles/…

IL-11 is a cytokine induced with age, regulates an ERK–AMPK–mTORC1 axis which contributes to age-associated tissue decline (Inflammaging). Blocking it show health benefit in aged mice. Beautiful new work by Stuart Cook lab & collaborators at MRC Laboratory of Medical Sciences (MRC LMS) nature.com/articles/s4158…

Super excited to announce that I have joined MRC Laboratory of Medical Sciences (MRC LMS) to start my group here lms.mrc.ac.uk/research-group…, continuing studies on AMPK & exploring its roles in immunity & ageing. Recruiting research technician to join my lab! #hiring #AMPK #metabolism #immunity nature.com/naturecareers/…

We're delighted that Nazma has joined us and is #hiring as she sets up her research group! Details below!

FANCI that! New #LMSResearch from David Rueda has solved the decades long mystery of how DNA damage by sunlight, alcohol and pollution is identified so it can be repaired. This discovery opens up opportunities for improved cancer treatments. lms.mrc.ac.uk/fanci-that-dec…

#WeekendRead! #ImmuneCannibalism! Wellcome #nexocytosis Cell Tim Lämmermann Lab, Mihlan &co! In #allergy, mast cells attract, eat, & kill neutrophils, steal their effectors & DNA that can be released afterwards to induce type I #interferons via cGAS dlvr.it/TBRsZ7

🚨New research in Nature Aging from the MRC Laboratory of Medical Sciences (MRC LMS) reveals that blocking longevity gene S6K1 extends lifespan by reducing inflammation, not by directly influencing cellular senescence. This opens new avenues for treating age-related diseases. 🧬✨ lms.mrc.ac.uk/blocking-the-l…

New paper out nature - why are males more vulnerable to severe infections (ex acute #COVID), while females suffer more from autoimmunity (SLE, MS etc and also #LongCovid)? sex chromosomes or hormones? Here we studied adaptation of human immune systems to gender-affirming

We are thrilled to welcome Nazma Malik to the MRC Laboratory of Medical Sciences (MRC LMS) where she will head up the Metabolism in Immunity, Cancer and Ageing group! Read more about her work and reasons for joining the LMS below! lms.mrc.ac.uk/introducing-dr…

The anti-aging impact of metformin (randomly assigned, with controls) in male monkeys after 40 months of treatment, a pan-omic clock assessment —~6 year regression of brain aging, with prevention of atrophy and enhanced cognitive ability —minimal effect on blood sugar —evidence

📢3-year postdoctoral fellow position available Interested in gene regulation and deciphering the molecular mechanisms of human disease, join us at the MRC Laboratory of Medical Sciences (MRC LMS) in the beautiful city of London For more details, please visit lms.mrc.ac.uk/vacancies/mrc-… ✉️[email protected] 🙏RT

Congratulations to Zhijian “James” Chen, 2024 #LaskerAward winner! – “for the discovery of the cGAS enzyme that senses foreign and self DNA, solving the mystery of how DNA stimulates immune and inflammatory responses.” laskerfoundation.org/winners/cgas-e… #Lasker2024 #LaskerLaureate

🦕Welcome to the Jurassic era of STING! Online Molecular Cell We uncovered a primordial role of the cGAS-STING pathway in lysosomal biogenesis & stress clearance, revealing its ancient function predating type I interferons. authors.elsevier.com/a/1joCM3vVUPRm… Kudos to Bo Lv & coauthors!! 1/n