A chance to work with an absolutely top-notch group of editors and an incomparable Chief Ed, Andy Marshall

In addition to the science, the most impressive thing about this effort was 23 first authors, working together tirelessly (with little sleep) with collegiality and partnership of the likes I have never seen. Kudus to the co-first author team and everyone that contributed

Volker Bergen Really excited that our #scVelo update led by Volker Bergen is out - you can now do nicer plots, look deeper into the velocities and in particular test for celltype-specific dynamics, as here Tmsb10 differential in endothelial cells (black). Vignettes at scvelo.org

Congratulations, Laleh! I'm sure that you'll do great things!

Scientific American, the longest continuously published monthly serial in the US, announces the first political endorsement in its history. Very strong editorial. scientificamerican.com/article/scient…

#WhatAreciboMeansToMe: More than a telescope, Arecibo is the reason I am even in astronomy, and has had an incalculable impact in the communities of PR. A thread 🧵.

We are sad to say goodbye to Arecibo (Arecibo Observatory), but we're grateful for its phenomenal contributions to space science and planetary defense. What does Arecibo mean to you? #WhatAreciboMeansToMe sciencemag.org/news/2020/11/f…

Huge congratulations to John Marioni for his appointment as our new Head of Research. 👏 🎉 Learn more about John’s vision for research at EMBL-EBI and his future plans. MarioniLab @EMBL. ebi.ac.uk/about/news/ann…

Our first Human Tumor Atlas (HTAN) paper, jointly with the Rudin's lab on Small Cell Lung Cancer is ready. A stepping stone toward understanding this terrible disease. Kudus to the amazing team: Joe Chan, Alvero Quinta, Vianne Gao and Tal Nawy biorxiv.org/cgi/content/sh…

MSK mourns the loss of our esteemed colleague Kathryn Anderson. Under her leadership as Chair of the Developmental Biology Program & first female chair of a SKI program in decades, Dr. Anderson developed one of the nation's top programs & a model for gender diversity in science.

MSKCC's Single Cell Research Center is expanding and hiring computational research scientists and data analysts. For more information: mskcc.org/research/ski/l…

The Single Cell Innovation Lab (under my direction) is expanding and has a number of exciting computational biology staff positions open for algorithmic development, data analysis and software development. Please apply at tinyurl.com/mstn4hxv and tinyurl.com/bddtjybj

Finally published in Nature Methods: CellRank for directed #SingleCell fate mapping, our take on studying cellular dynamics using RNA velocity. Fantastic collab between labs of dana_peer @sloan_kettering and Fabian Theis Helmholtz Munich | @HelmholtzMunich, read at go.nature.com/3Fm17lt. 1/17

1. Thrilled and proud to announce our latest preprint: Spectra -Supervised discovery of interpretable gene programs from single-cell data. It is a factorization method that really works and is already in intensive use across projects in my own lab --> doi.org/10.1101/2022.1…

Super excited to share the first preprint from Karuna Ganesh Lab! An amazing collaboration with dana_peer, led by the phenomenal andrew moorman @f_cambuli and Ellie Benitez Memorial Sloan Kettering Cancer Center. Progressive #Plasticity during #ColorectalCancer #Metastasis. biorxiv.org/content/10.110…

Excited to share our preprint "Multiome Perturb-seq unlocks scalable discovery of integrated perturbation effects on the transcriptome & epigenome". This work extends single-cell CRISPR screens to simultaneously profile gene expression & chromatin accessibility.

On bioRxiv today, we raise serious concerns over a recent @nature paper describing ReDeeM, a new single-cell mitochondrial DNA (mtDNA) sequencing / analysis method. Here are three things that you need to know: 1/n biorxiv.org/content/10.110…

Important warning for cellular lineage tracing studies base on mitochondrial DNA - the level of variant support really matters!

Thank you Chen Weng, @jswlab, Vijay Sankaran for the feedback on our work. LeifLudwig and I agree that the “-2” filtering method that mitigates edge bias is a critical development for ReDeeM. Nevertheless, we stand by our original preprint, noting the following: 1/n