Hypertension can be genetically🧬 deconvoluted into primary aldosteronism (WNT2B, TBX3, LSP1, RXFP2, HOTTIP, CYP11B1/B2) and vascular traits (RNF213). Nice works with TatsuhikoNaito, Kosuke Inoue, Kenji Oki. Now in Circulation #PrimaryAldosteronism #GWAS doi.org/10.1161/CIRCUL…

#OriginalResearch: Genetic risk of primary aldosteronism and its contribution to hypertension: a cross-ancestry meta-analysis of genome-wide association study TatsuhikoNaito YukinoriOkada #AHAJournals ahajrnls.org/3Ixe6V3

Our new preprint is out! We coprehensively analyzed WIPI family proteins using Halo-tag based processing assay. Congratulations, Takahiro!! biorxiv.org/content/10.110…

#Editorial Contextualizing the original research article from TatsuhikoNaito YukinoriOkada examining the Genetic Risk of Primary Aldosteronism and possible contribution to #Hypertension #AHAJournals ahajournals.org/doi/10.1161/CI…

～今年もやります、遺伝統計学・夏の学校～ We have "online" summer school of Statistical Genetics🧬🖥️💊. Aug 25th-27th, 2023📅by Osaka Univ, Univ Tokyo, RIKEN IMS. Any students with interests in stat genet are welcome !! #Genetics #gwas #SummerSchool #omics sg.med.osaka-u.ac.jp/school_2023.ht…

【追加募集】東京大学大学院医学系研究科 遺伝情報学では、遺伝統計学やゲノム・オミクス解析による病態解明・創薬・個別化医療に一緒に取り組むIT系技術補佐員を【さらに一名】募集中です。バイオバンク・ジャパン(BBJ)のデータ解析チームの一員としても活躍して頂きます。 m.u-tokyo.ac.jp/news/jobs/2023…

If you're at #ASHG2023 #ASHG23 check out the various talks and posters from members of the David A Knowles (@davidaknowles.bsky.social) and Towfique Raj labs

Association of polygenic score for thyroid hormones with various diseases. Note the pleiotropic associations with autoimmune diseases which are due to binarized thyroid hormone GWASs (high/low TSH) capturing autoimmune thyroid disease loci. Interesting! nature.com/articles/s4146…

Happy to share the latest #GWAS of multiple #thyroid traits from the ThyroidOmics Consortium, published in Nature Communications!! I feel honored to have been involved in this great study! nature.com/articles/s4146…

Additionally, our review paper on the application of deep learning to genotype imputation has been recently published in Journal of Human Genetics HumanGenetics 日本人類遺伝学会-!! This is open access! nature.com/articles/s1003…

The CAGI flagship paper establishes progress and prospects for computational genetic variant interpretation methods. It draws conclusions from the first 10 years of CAGI assessments genomebiology.biomedcentral.com/articles/10.11… 1/n

医学のあゆみ 特集「遺伝統計学の新潮流」が発刊されました。執筆頂いた皆様に感謝です。 amazon.co.jp/dp/B0CZ8SN3J4

I am honored to have been awarded the BrightFocus Foundation Fellowship and am committed to giving my utmost effort in researching Alzheimer's disease. Huge thanks to my mentors, Towfique Raj and David A Knowles (@davidaknowles.bsky.social)!

【新刊】実験医学増刊号『大規模データ・AIが切り拓く脳神経科学』が本日発行．深層学習と脳画像DBの活用で，精神・神経疾患の診断は「主観的な尺度による診断」から次の段階へ．高次脳機能を生む脳領域間相互作用の新知見も必見！ yodosha.co.jp/yodobook/book/…

～今年の遺伝統計学・夏の学校は「応用編」～ We have "onsite" Summer School⛱️🏫of Statistical Genetics🧬at Univ Tokyo (Aug 31-Sep 1). Advanced English course on Polygenic Risk Score (PRS) analysis with Paul O'Reilly at Icahn School of Medicine at Mount Sinai. #gwas #PRS #omics sg.med.osaka-u.ac.jp/school_2024.ht…

Our #GWAS🧬 paper on unexplained recurrent pregnancy loss comes out in Nature Communications! We analyzed 1,728 cases and 24,315 female controls, implicating the HLA and cadherin-11 gene with its unexplained etiology. I appreciate all the study participants. nature.com/articles/s4146…

We are happy to announce that scLinaX paper is finally published in Cell Genomics 🐧!! If you are interested in escape from X chromosome inactivation, a mechanism contributing to sex difference of transcriptome, please check our paper! cell.com/cell-genomics/… Tweetorial↓

Last chance to register for our PRS Workshop in Tokyo!! See details here -> sg.med.osaka-u.ac.jp/school_2024.ht… Please RT 🙏