This Scientific Reports article shows that lncRNA GHET1 released by bone mesenchymal stem cell–derived exosomes ameliorated doxorubicin-induced #pyroptosis by targeting 🎯 IGF2BP1 to reduce posttranscriptional stabilization of NLRP3. 📖 Read more: go.nature.com/3AwAhdD

The joint leadership of Drs. Cintia Folgueira & Leticia Herrera-Melle showed that exercise 🏋️ activates muscle p38γ, increasing locomotor activity through the secretion of IL-15. IL-15 signals 🚥 in the motor cortex, stimulating #locomotor activity. Guadalupe Sabio CNIC

🛰️ Satellite cells endow skeletal muscle with the ability to regenerate after a severe injury and this #myogenic potential of satellite cells requires a protein called tripartite motif-containing 28. This discovery was made by the The Hornberger Lab and published recently in

In this report, Chiang Mai University researchers showed that trastuzumab-induced cardiotoxicity (TIC) is involved with autonomic imbalance and #cardiomyocyte death. ☠️ TIC could be improved by vagus nerve stimulation-mediated mAChR and nAChR signaling. bit.ly/3T377Jw

🚨New preprint from our group🤩 Muscle Fibroblasts and Stem Cells Stimulate Motor Neurons in An Age and Exercise-Dependent Manner Great work by Casper Casper Søndenbroe to bring this together💪 🙏Ben Chazaud Institute of Sports Medicine Copenhagen Supported by Lundbeckfonden biorxiv.org/content/10.110…

📚 This study showed that elastin degradation, matrix metalloproteinase activity, macrophage infiltration, ROS production, collagen fibers remodeling, and VSMCs senescence were decreased in abdominal aortic #aneurysm treated with vinpocetine. Check it out!

🔬 Scientists with Dr. Shijie Liu at The Texas Heart Institute developed YAP-K265R and αMHC-MerCreMer; Yap-loxP/K265R mutant mice to examine the pathophysiological role of YAP acetylation in #cardiomyocytes during 💓 cardiac regeneration. Circulation | bit.ly/3WU15vO

Scientists at FLORIDA discuss how exercise training 🏋️ influences key antioxidant enzymes in skeletal muscles 💪 and review the Nrf2 signaling pathway responsible for #exercise-induced changes in muscle antioxidant capacity. 📖 bit.ly/3YZbWak

🔎 Scientists with Dr. Dorien Laenens at LUMC Leiden investigated whether the H2FPEF score was associated with 💓 heart failure outcomes in patients with hypertrophic #cardiomyopathy. 👉 bit.ly/3X61w6t

Hydrogen sulfide (H2S), the third #gasotransmitter discovered, 🚦 regulates various physiological functions. Scientists studying whether H2S alleviates skeletal muscle 💪 aging by regulating #autophagy has not been reported. Journal of Cachexia, Sarcopenia and Muscle | bit.ly/3AFyL8V

Researchers explored the molecular target 🎯 and underlying mechanism of betaine in attenuating the age-related #mitochondrial dysfunction in skeletal muscle. 👉 bit.ly/3X7gVmG

Dr. Andreas Patsalos and scientists at Johns Hopkins Medicine reconstructed the dynamic trajectories of #myeloid cells isolated from acutely injured and early-stage dystrophic 💪 muscles. 👓 Check out their findings at Journal of Clinical Investigation | bit.ly/475lsLg

In this study, the direct effects of #insulin on vascular smooth muscle cells (VSMC) to alter plaque composition were studied using mice with double knockout of ApoE and #insulin receptors 🧬 genes in VSMC. 🔗 bit.ly/3X754oR

Scientists at Mizzou demonstrated that endothelial-specific #endothelial cell-specific CD36 signaling 🚥 participated in skeletal muscle-free fatty acid uptake and associated skeletal #muscle dysfunction in diet-induced obesity. AJP-Endocrinology and Metabolism | 👉 bit.ly/4cLx0Eo

👇 Check this out! Dr. Brennan Wadsworth (Wadsworth) and scientists at Karolinska Institutet showed that 2-hydroxybutyrate regulated 🎮 the fundamental aspects of skeletal muscle #metabolism! eLife - the journal | bit.ly/3XwBN8F

“To Postdoc or Not to Postdoc?” 💭 In this episode of the Lab Coats & Life Podcast, educator and career coach Dr. Jennifer Polk (Jennifer Polk, PhD (she, her)) chats about key things to consider when approaching this big question. Check it out! 👀 bit.ly/3YOteXF

🔎 In this study, investigators at Wake Forest University School of Medicine with Dr. Bumsoo Ahn investigated the long-term effects of unacylated ghrelin in age-associated #MuscleAtrophy and contractile dysfunction in 🐭 mice. Aging_Cell | bit.ly/3yU0YIR

Trying to stay on top of all things muscular? 💪 🧐 Check out the Science News website by STEMCELL Technologies and subscribe to our bi-weekly newsletters covering the latest research, reviews, industry news, and more. 🔗 bit.ly/3VjfjHp

🔎 Scientists explored the impact of Nesfatin-1 on type 2 #diabetic erectile dysfunction and its underlying mechanism in regulating the phenotypic switching of corpus cavernosum smooth muscle cells. PLOS ONE | bit.ly/3MxlBNX