Well done Paula SG for defending our poster with verve!

MBE latest: Evolution of an amniote-specific mechanism for modulating ubiquitin signalling via phosphoregulation of the E2 enzyme UBE2D3 dlvr.it/RRR7bm

Lights off in the lab. Computers on at home. Time to learn new skills 'in silico' with Monica Roman Trufero Paula SG Marilena Christoforou HAA and Elena LJ

How do #cancer cells that survive chemotherapy resolve stress? Turns out it’s complex & generates druggable weaknesses. See our new paper now out in PNAS (1/8).🧵pnas.org/content/118/17…

We used a temporal multi-omics approach to study stress resolution in #myeloma cells treated with a #proteasome inhibitor (2/8).

Huge changes across cellular systems included a dynamic shift in energy metabolism from increased glycolysis during acute stress to fatty acid catabolism in recovering cells, which also suffered from compromised mitochondrial function and amino acid shortages (3/8).

So, does resolving stress cause more stress (4/8)?

Yes! Drugs targeting mitochondria or the amino acid response impaired myeloma cell recovery and had effects on the transcriptome and metabolome that were very different from those observed in unstressed or acutely stressed cells (5/8).

The data suggest that resolution of cellular injuries is accompanied by new challenges for cancer cells in the sense of ‘trade-offs’, revealing weak spots in the cancer cell armour (6/8).

@KEvinBlighe👨‍💻then constructed an analysis tool to test if our findings in stressed #myeloma cells could be useful for finding treatment targets in other cancers that aren’t stressed...computer says ‘YES’ (7/8)!

We have a new #myeloma target and it's a cool kinase called #GCN2. Identified as a #metabolic vulnerability by us Imperial College London earlier this year pnas.org/content/118/17… now elegantly linked to MM progression by the Trudel and Pugh Lab in nature.com/articles/s4146…

👏🏻👏🏻👏🏻👏🏻 Teresa Suarez

New Research: Multiple myeloma metabolism – a treasure trove of therapeutic targets?: Multiple myeloma is an incurable cancer of plasma cells that is predominantly located in the bone marrow. Multiple myeloma cells are characterized by… frontiersin.org/articles/10.33… #immunology

Intrigued by #myeloma metabolism but not too keen on heavy-duty biochemistry? Check out or MINI REVIEW "Multiple myeloma metabolism – a treasure trove of therapeutic targets?" by Monica Roman Trufero @DrClaireEd and myself frontiersin.org/articles/10.33…

Our #myeloma research centre is up and running Imperial Department of Immunology & Inflammation and ready to deliver groundbreaking translational research imperial.ac.uk/news/239313/ne…

Monica Roman Trufero presenting data on how GCN2 helps stressed #myeloma cells survive #ehaRecon22 in Palermo. Work by Paula SG HAA Jessica Hill @KevinBlighe Martin Kaiser Diego Oyarzún and many others. Find some of the data here in detail doi.org/10.1073/pnas.2…

Teresa Suárez, del grupo Laboratorio 3D: desarrollo, diferenciación y degeneración:

instagram.com/reel/Cs3u5GVo5…

“Y hay un niño que pierden todos los poetas” #FedericoGarcíaLorca , el crío que no mira a cámara, el pequeño Federico. #125Cumpleaños

El 23 de octubre de 1936 Antonio Machado publica en "El liberal" el poema "El crimen fue en Granada", en homenaje a Federico García #Lorca Esta es una copia de la edición de ese día con la primera impresión del poema: