Win the IND pumpkin carving contest 2 years in a row - ✅ Congrats to the team! Taylor Watanabe Julie Smeyers Lin Yadanar

Are you an incoming UCSF grad student interested in doing research in neurodegeneration? If you are, join us at the IND OPEN HOUSE @ Helen Diller on 11/15 to meet our current trainees and faculty and to discuss their research! Register here: forms.gle/sqTX5GLNoHiGym…

Really excited about our latest preprint, where we uncovered a neuroprotective role for neuronal polyunsaturated fatty acids in FTD and ALS. Led by Ashling Giblin and Alex Cammack biorxiv.org/cgi/content/sh… 1/9

Exciting study from the Gitler Lab: TDP-43 nuclear loss in FTD/ALS causes widespread alternative polyadenylation changes biorxiv.org/content/10.110…

Excited to share this review on one of my favorite biological problems: Selective vulnerability in neurodegenerative disease, and how recent technologies are yielding new insights into the underlying mechanisms. Out in Nature Rev Neurosci today! nature.com/articles/s4158…

Check out the data that goes along with our new manuscript & conduct an exciting secondary analysis of your own! The Rainwater Charitable Foundation Alzheimer's & Dementia Journals

Excited to finally share work from a past life! In this small study we dissect neuronal vulnerability, myelin dysfunction and microglia activation in #ALS read our full work on Nature Aging nature.com/articles/s4358…

Rapid iPSC inclusionopathy models shed light on formation, consequence, and molecular subtype of α-synuclein inclusions: Neuron cell.com/neuron/fulltex…

The Target ALS #DataEngine just got bigger! We’ve expanded datasets across all core collections, added a user manual, and released new demo videos. Now it’s easier than ever to explore and utilize rich data for #ALSResearch. Explore the updates: bit.ly/3yVk2GF

Deciphering Distinct Genetic Risk Factors for FTLD-TDP Pathological Subtypes via Whole-Genome Sequencing medrxiv.org/content/10.110…

Had a lot of fun at lab lunch! Welcome to the lab, Nicole and Lisa!

Excited to announce new funding from the NIA to investigate the connection between defects in protein homeostasis and neurodegeneration. #FTD #dementia #ALS

Out Science Magazine! New tech to activate ALS gene therapies only in the right cells at the right time - Increased safety to have more options for ALS. We do it by taking advantage of cryptic splicing. science.org/doi/10.1126/sc… UCL Queen Square Institute of Neurology The Crick Oscar Wilkins Max Z. Y. J. Chien

Had a great time at the Oktoberfest IND collaboration hour! Thanks to everyone who stopped by.

Inhibition of RNA splicing triggers CHMP7 nuclear entry, impacting TDP-43 function and leading to the onset of ALS cellular phenotypes cell.com/neuron/fulltex…

Excited to share new study from the lab, work led by John and grateful for all the collaborators who made this possible including ChangLabUCSF UC Santa Cruz Genomics Institute

In this study, we observed that a C9ORF72-ALS/FTD dipeptide repeat protein perturbs the phosphorylation of RNA binding proteins and STMN2 expression, and found that SRSF7 sustains STMN2 levels in induced neurons. Congrats to Julie Smeyers and Karen! #ALS actaneurocomms.biomedcentral.com/articles/10.11…

Deciphering distinct genetic risk factors for FTLD-TDP pathological subtypes via whole-genome sequencing: nature.com/articles/s4146…

Regulation of translation elongation and integrated stress response in heat-shocked neurons: Cell Reports cell.com/cell-reports/f…

Excited to share our Cell Reports article! We investigated how the loss of TBK1 function contributes to ALS and dementia using human stem cell-derived neurons and advanced proteomics. Many thanks to all co-authors for their great work and collaboration! sciencedirect.com/science/articl…