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Ammonium acetate does not buffer at neutral pH, but we have no better option for native MS. But what if I told you we've uncovered an alternative? doi.org/10.1021/acs.an… By extraordinaire PhD student, Brad Davis MCB at UofG ACS for Authors ACS Analytical Chemistry Journals Advancing Mass Spectrometry Native MS-Guided Structural Biology Center

Fungal fatty acid synthases are key drug targets against opportunistic infections affecting immunocompromised patients. Our team, led by Elnaz Khalili Samani, has developed a protein engineering strategy to delve into the complex mechanisms of these synthases. rdcu.be/dvRmQ

Targeted Mass Spectrometry of Longitudinal Patient Sera Reveals LTBP1 as a Potential Surveillance Biomarker for High-Grade Serous Ovarian Carcinoma | Journal of Proteome Research pubs.acs.org/doi/10.1021/ac…

Presenting my work today Biophysical Society annual meeting in the Protein Structure and Conformation platform as flash talk and on Wednesday in the poster session. #bps2024

Checkout our new paper, describing a simple method to analyze low amounts of flow sorted cells by Matt Waas and team Droplet-based proteomics reveals CD36 as a marker for progenitors in mammary basal epithelium: Cell Reports Methods cell.com/cell-reports-m…

Congratulations ⁦Matt Waas⁩ for securing the cover for his Dropps paper cell.com/cell-reports-m…

Proteomics on 800 urine fractions from prostate cancer patients (soluble fraction and EVs). Outstanding work by Amanda Khoo Meinusha and Zhuyu Qui. It was a long process to get this published nature.com/articles/s4146…

A study led by talented PhD student David Dai reveals a potential association between a massive centrosomal scaffolding protein (encoded by the AKAP9 gene) and dsDNA. Read more: doi.org/10.1101/2024.0…

An exciting study lead by talented PhD student Elnaz Khalili Samani revealed cryoEM structures of native protein assemblies from brain lysate of a rat model of Alzheimer's disease. Collaboration with JoAnne McLaurin and Thomas Kislinger. doi.org/10.1101/2024.0…

Last weekend I had the pleasure to attending the Walk to Conquer the Cancer hosted by the The Princess Margaret Cancer Foundation Enjoyed showing DNA extraction to the participants.

1/🧵Human ClpP protease is targeted in cancer therapy with the activator ONC201 Chimerix, Inc. Yet all structures of ClpP have captured it in its inactive state, even when bound to activators! ClpP is paradoxically activated by inhibitors at low concentrations before inhibition starts

Happy to share our little discovery with Simone Mattei team on how ribosomes hibernate upside down on mitochondria during cellular stress is now out Nature Communications! A collaboration between @medicineUVA, @EMBL, EMBL Imaging Centre, MEMC. Congrats to all authors! nature.com/articles/s4146…

I am looking for a highly talented postdoc to join my lab to study ATP-dependent AAA machines using structural biology, biochemistry, and mass spectrometry. Please apply through the following link: bit.ly/4haSZID For more information, visit: sites.wustl.edu/ghanbarpour/

We are recruiting! Princess Margaret Cancer Centre in Toronto is recruiting an early career cancer research scientist at Assistant Professor level. Apply! Spread the word! nature.com/naturecareers/…

Excited to see this work published. A great collaboration between multidisciplinary research groups driven by talented PhD student Elnaz Khalili Samani

Latest work from our group by Elnaz Khalili Samani We used Build and Retrieve (BaR) method to reconstruct cryoEM maps from crude protein purification sourced from Alzheimer’s disease model rat brain.

Big effort (> 7 years) from a large number of colleagues. Finally on BioRxiv and to be submitted in January Pan-cancer N-glycoproteomic atlas of patient derived xenografts uncovers FAT2 as a therapeutic target for head and neck cancers biorxiv.org/content/10.110…

Protein scavenger inspires new drug design✨ Scientists unveiled an essential protein degradation process in mitochondria, offering new ideas to curb cancer cells’ energy supply. A study in pnas led by Drs. Aaron Schimmer University Health Network and Siavash Vahidi University of Guelph. pnas.org/doi/10.1073/pn…

How exanctly does lipid-siRNA organization control the intracellular dynamics of LNPs? Our latest J. Am. Chem. Soc. article provides insights on the link between LNP internal structure and its intracellular delivery profiles. 🧬 Gang Zheng Gang Zheng Lab pubs.acs.org/doi/10.1021/ja…

Excited to share a great new study from Dr. David Dai (David Dai) revealing a potential new role for the centrosomal protein AKAP350 in binding double-stranded DNA: authors.elsevier.com/a/1kvEy54HFZNBO