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PostDoc opportunity! We are looking for an enthusiastic #PostDoc to study how mitochondrial dysfunction contributes to the pathogenesis of neurodegenerative disease. Join my research group within Division of Molecular Metabolism, KI Karolinska Institutet ki.varbi.com/en/what:job/jo…

Presenting metabolomics analyses: what is in a number? embopress.org/doi/full/10.10… JMeiser_lab and I wrote this short piece to raise awareness about how present metabolomics data. We hope you will find it useful. Any comment is welcome! thanks Daniel Klimmeck for the support!

Nytt blogginlägg av Akademiens ständige sekreterare: Ökad kontroll och ökad byråkratisering Läs Hans Ellegrens kommentarer 👇 sekreterarensblogg.wordpress.com/2024/04/29/oka…

A KI study published in Nature Metabolism today shows that a specific class of drugs that block mitochondrial function can reverse diet-induced #obesity, fatty liver and #diabetes in mice. #metabolism news.ki.se/new-drug-candi…

Read our new study: nature.com/articles/s4225… Treatment of obese mice with small molecule inhibitors of mtDNA transcription (IMTs) leads to marked beneficial metabolic effects. The weight is normalized, the fat deposition in liver disappears and glucose homeostasis is normalized.

Our study is finally out! nature.com/articles/s4153… We here show that PARKIN is dispensable for OXPHOS function in adult mouse tissues and in skeletal muscle from a PD-patient. Thanks to Nils-Göran Larsson , Motori Lab, Thomas Perlmann and Per Svenningsson for the great collaboration!

Researchers at Karolinska Institutet may have found a new way to treat #obesity and related disorders by targeting the cells’ powerhouses, the mitochondria #Research supported by Knut and Alice Wallenberg Foundation #KAW100 #metabolism #diabetes bit.ly/4baXLlw

Forskare Karolinska Institutet kan ha hittat ett nytt sätt att behandla #obesitas och besläktade tillstånd genom att rikta in sig på cellernas kraftverk, mitokondrierna #forskning med stöd av Knut och Alice Wallenbergs Stiftelse #KAW100 #fetma #diabetes bit.ly/3QtR5qN

Congratulations Sandra! Well deserved!

Grattis Maria! Välförtjänt!

Great opportunity to start your own research group! Go ahead and apply!

Happy to see our latest paper out today in Nucleic Acids Res. A beautiful collaboration with Annika Krüger, Joanna Rorbach Division of Molecular Metabolism, KI, Hana Antonicka and Eric Shoubridge. Antonio Barrientos ahram ahn bit.ly/3WyuPiE

New paper from us on the in vivo role of the LRPPRC/SLIRP protein complex and its crucial role in mammalian mtDNA gene expression: academic.oup.com/nar/advance-ar… Congratulations Diana Rubalcava for great work! Thank you to all coauthors for a very nice collaboration.

This will be agreat meeting. Looking forward to attend!

Great work! Congratulations Roberta and coworkers.

Excellent conference organized by Nora Voegtle and Ricarda Richter-Dennerlein. “Mitochondria in life, death and disease”. meetings.embo.org/event/24-mitoc…

News and Views from us on maternal transmission of mtDNA: rdcu.be/dSWDA In addition to the bottleneck mechanism and purifying selection in early oocyte development, elegant experiments show that purifying selection also occurs during postnatal mouse oocyte development.

Happy to share our latest manuscript on using quantitative proteomics to diagnose patients with mitochondrial disease. Great collaboration with Taylor Lab and Lukas Käll insight.jci.org/articles/view/…

Excited to have published our work on #SEQURNA, a next-generation RNase inhibitor transforming #scRNAseq & other applications. ➡️Introducing synthetic thermostable RNase inhibitors to single-cell RNA-seq 🚀 🌕 nature.com/articles/s4146… 🧵…

New study from us: science.org/doi/10.1126/sc… High mtDNA copy number promotes lung cancer growth in the mouse, whereas mtDNA depletion in tumor cells reduces tumor growth. This tumor-intrinsic role for mtDNA can be exploited for development of future lung cancer therapies.