Our story about interactions between anti-phage defense systems is now in Cell Host & Microbe: sciencedirect.com/science/articl…

Really excited to talk at #TAGC24 about our project with Evan Koch on population genetics of effect size correlations in GWAS

1/ We’re excited to share our new preprint “Dissecting the contribution of common variants to risk of rare neurodevelopmental conditions” available on medRxiv! medrxiv.org/content/10.110…

Discussed Spence et al. [biorxiv.org/content/10.110…] for journal club. Very nicely draws the connection between estimating posterior GWAS effect sizes and many downstream parameters we care about: polygenic scores, genetic correlation, fine-mapping, etc.

We know that DNA introgressed from one population into another is often deleterious, but why? Carl Veller and I show that stabilizing selection, by itself, can induce selection against introgressed ancestry. doi.org/10.1101/2024.0…

I am excited to share that I will be starting a lab at Emory University this September. We will aim to understand evolution by studying genomes of things ranging from viruses to humans. Looking for talented students and postdocs to do computational genomics. Get in touch! 1/2

Excited to share our preprint: Cohort-level analysis of human de novo mutations points to drivers of clonal expansion in spermatogonia! We developed methods to uncover drivers of clonal expansions in sperm (CES) using 55k disease trios & gnomAD SNV data. medrxiv.org/content/10.110…

Our latest work is out in Nature today. In this paper, we introduce an improved version of NanoSeq, a duplex sequencing protocol with <5 errors per billion bp in single DNA molecules, and use it to study the oral somatic mutation landscape in >1000 people. nature.com/articles/s4158…

Our paper on clonal expansions in Sperm is out in Nature nature.com/articles/s4158… If you are interested in working at an intersection of Mendelian genomics/Population genetics/Clonal expansions +Cancer genetics/ and of course mutagenesis, please rich out about postdoc in my lab

Our work on sperm sequencing is now published! See below for: 🧑‍🔬Scientific tweetorial 📰 Accessible articles discussing implications for aging fathers [1/3] nature.com/articles/s4158…