This is a landmark paper on the heritability of human traits👇 Using WGS data from 350K UK Biobank participants, the study shows that rare (>0.01%) and common (>1%) variants across coding and non-coding regions explain almost all (on average 88%) of the heritability (as

8 Resources to study Transcription factor binding, enhancers and histone modification distribution  1. ENCODE encodeproject.org

Biological Age Predictors - eBioMedicine thelancet.com/journals/ebiom…

Epigenetics Update - Lineage-determining transcription factors constrain cohesin to drive multi-enhancer oncogene regulation go.nature.com/3Me82WO #Epigenetics #Cohesin #Chromatin --- Discover the breakthrough at epigenometech.com

Now online! Retraction notice to: Transcriptome-scale RNA-targeting CRISPR screens reveal essential lncRNAs in human cells dlvr.it/TPdpN6

Biobank Japan now offers GWAS data for NMR metabolomics (N=37,969), as well as a multi-ancestry meta-analysis with UK Biobank & Estonian Biobank (total N=657,341). The data cover 248 metabolites and expand our metabolomics resources for following-up GWAS signals.

Our new paper is out nature 🎉. We show that m1Ψ in mRNA vaccines doesn’t just quiet immunity, it also directly enhance translation by reshaping ribosome dynamics in a sequence-dependent way 🧬 Full paper : rdcu.be/eY5gx

New GWAS of age-related hearing loss in a massive sample of 456,613 cases & 1,053,834 controls detects 140 loci. Hearing loss is a huge unmet need with >25% of people >60y affected and no available pharmacotherapy. If you want to find promising drug targets, start here!

New online! The AlphaGenome deep learning model predicts effects of non-coding variants dlvr.it/TR786Z

ctOTVelo: Cell type-specific gene regulatory network inference from single cell transcriptomics biorxiv.org/content/10.648…

Comparing bulk and single-cell methodologies and models to profile gene expression, chromatin accessibility and regulatory links in ... biorxiv.org/content/10.648… #biorxiv_genomic

Epigenetics Update - An H3K4me3 reader recruits the positive transcription elongation factor B complex to facilitate transcription elongation in Arabidopsis bit.ly/4bqInnQ #Epigenetics #H3K4me3 #Plants #Arabidopsis --- Discover the breakthrough: epigenometech.com

New! Online now: Metabolic polygenic risk scores for prediction of obesity, type 2 diabetes, and related morbidities dlvr.it/TRWmz4

AGT (angiotensinogen) is a key component of the renin-angiotensin-aldosterone system (RAAS). RAAS is the target of multiple successful hypertension therapies. AGT is produced in the liver by hepatocytes, making it a promising target for GalNAc-delivered RNA-based therapeutics.

New! Online now: Plasma proteomic signature of frailty in 50,506 adults dlvr.it/TRX37X

Nature research paper: Multidimensional profiling of heterogeneity in supratentorial ependymomas go.nature.com/4brosUV

The GTEx v10 eQTL data have been integrated into the SMR portal: yanglab.westlake.edu.cn/smr-portal/

Macrophage senescence is a central driver of chronic inflammation in aging and metabolic liver disease, and a tractable therapeutic target.

New preprint: mass cytometry across 351 blood + CSF samples, two cohorts, full AD continuum. Peripheral immune signatures (pAkt in naïve T killer cells, pPLCγ2 in granulocytes) emerge in preclinical AD, before plasma ptau217, CSF ptau181, and DCE-MRI BBB disruption. Not seen in