The name of this protein was inspired by Pikachu's "lightning-fast moves". That's interesting..

An interesting new study that discusses various pathways of G protein-coupled receptor (GPCR) internalization and reveals that the GLP-1 receptor undergoes both beta-arrestin-independent and beta-arrestin-dependent internalization processes: biorxiv.org/content/10.110…

Amazing work by Arun K. Shukla group on chemokine receptors that sheds light into different modalities of agonist binding, GPCR dimerization, biased signaling and more. #GPCR biorxiv.org/content/10.110…

In our article published today nature , we report complete all-atom structural models of a fully packaged bacteriophage particle. Congratulations to Kush Coshic on his first publication! Many thanks to Chris Maffeo and David Winogradoff for pushing this 6-year project forward.

THEY SAID WE COULDN'T DO IT........well, no one actually said that. But in our updated manuscript with Casper Goverde, Nico Goldbach, and Bruno Correia we show you can now design soluble analogues of membrane proteins with preserved functional features! biorxiv.org/content/10.110…

New publication from the group: "Mechanistic insights into G-protein activation via phosphorylation mediated non-canonical pathway" sciencedirect.com/science/articl… #Gprotein #GPCR #MDSimulation Congratulations Kunal Shewani

Apparently, people in academia can no longer use words like 'delve' or 'intricate' in their writings. I wonder how LLM models learned these words. #humangptdetectors

The pioneers who laid the foundation for neural networks have been awarded the Nobel Prize in Physics! What a great choice.

Another Nobel for AI. Exciting times to work on scientific problems using AI tools.

Thrilled to share that I’ve successfully defended my PhD thesis today! Grateful for the journey and excited for the challenges ahead.

New preprint out: our latest study reveals how distinct phosphorylation patterns on GPCRs allosterically modulate the functions of beta-arrestin 1 and 2. biorxiv.org/cgi/content/sh… #biorxiv

Cool cover designed by Damian Bartuzi in my group. Read the paper too! (pubs.acs.org/doi/10.1021/ac…). Great collaboration with Rob Lane's lab.

Our study on the impact of distinct phospho-patterns on GPCRs in modulating β-arrestin 1 and 2 has been published in JCIM. Through MD & ML analyses, we reveal atomistic details of how different phosphorylations drive specific signaling outcomes. JCIM & JCTC Journals pubs.acs.org/doi/full/10.10…

Could not believe J. K. Rowling used ChatGPT to write Harry Potter and the Philosopher’s Stone. That book has em dashes on almost every page; around 900 of them in 350 pages!

Yeah, better for bouncing unbroken if you drop it on the floor. Just not as a lean protein source.

Pharmaceutical remedies.

So now using the title ‘Dr’ when you have a PhD is pretentious, and not using it is also pretentious. Amazing. We’ve officially reached the Schrödinger’s-cat stage of academic titles: both acceptable and unacceptable at the same time.

😊

Well. Certified quackery Vs uncertified quackery.