Huge congratulations to David Fidock and the team!

Design of proteasome inhibitors with oral efficacy in vivo against Plasmodium falciparum and selectivity over the human proteasome pubmed.ncbi.nlm.nih.gov/34548400/?utm_…

Happy to have our K13 paper by Barbara Stokes et al featured in a collection of malaria articles published by eLife - the journal! :-)

Our letter with Barbara Stokes and Kurt Ward to NEJM is out in response to Balikagala et al! Our gene editing studies suggest that a K13 A675V or C469Y mutation alone may not ensure high-level resistance to treatment with an artemisinin derivative! nejm.org/doi/full/10.10…

Improving in vitro continuous cultivation of Plasmodium cynomolgi, a model for P. vivax pubmed.ncbi.nlm.nih.gov/35470066/

Our review with Kurt Ward @JessLBridgford is now out in Current Opinion in Microbiology! We review recent advances in elucidating the mechanism of artemisinin resistance, driven primarily by SNPs in Kelch13 & also review resistance to partner drugs! sciencedirect.com/science/articl…

Very proud to finally have work from my Microbiology and Immunology Otago PhD project published. We successfully developed a protocol for in vitro CRISPR Cas9 modification of Plasmodium cynomolgi, as a model for investigating P. vivax drug resistance. academic.oup.com/jid/advance-ar….

Integrative Genetic Manipulation of Plasmodium Cynomolgi Reveals MultiDrug Resistance-1 Y976F Associated with Increased In Vitro Susceptibility to Mefloquine. ✅ Just Accepted 🔓 Open Access 🔗 bit.ly/3FS9bxO

Online now! Mitigating the risk of antimalarial resistance via covalent dual-subunit inhibition of the Plasmodium proteasome dlvr.it/SlMPnr #chembiol

Our paper is out in CellChemicalBiology! A huge thanks to everyone who contributed to this study! Dual targeting of P. falciparum proteasome subunits using covalent inhibitors provides a potential strategy for restoring ART activity & combatting malaria! dlvr.it/SlMPnr

Thanks Phil Rosenthal for this excellent commentary on our recent study on proteasome inhibitors in CellChemicalBiology! The Fidock Lab Ioanna Deni

It's all about covalent inhibitors! See how covalent macrocycles that target the malaria proteasome can prevent resistance. Great work from the Bogyo lab John Bennett in collaboration with The Fidock Lab. biorxiv.org/content/10.110…

Really happy to have this work published. It's been great working with Matthew Bogyo and John Bennett on this project.

Important article just out in NEJM describing increasing numbers of #malaria parasites with resistance to first-line drugs in Eritrea. nejm.org/doi/full/10.10… These and our findings in Ethiopia are cause for concern in the Horn of Africa. nature.com/articles/s4156…

Our new paper with Didier Menard's group (and other brilliant collaborators) shows the concerning emergence of partial artemisinin resistance in Eritrea, along with deletions of hrp2 and hrp3.

Progress in malaria control in some countries in sub-Saharan Africa is challenged by several new threats, including artemisinin-resistant P. falciparum parasites with deletions in hrp2 or hrp3. Read the full Perspective by Brian Greenwood, M.D., from London School of Hygiene & Tropical Medicine:

Sad to say goodbye to all of my brilliant colleagues at the The Fidock Lab after finishing up my first postdoc, but really excited to start working with @ProfJakeBaum at UNSW!

Wonderful to have our work published in Science Advances! An enormous amount of work over many years, and a great group effort led by Sachel Mok and The Fidock Lab. Very happy to have been part of this project. science.org/doi/10.1126/sc…

Mapping the genomic landscape of multidrug resistance in Plasmodium falciparum and its impact on parasite fitness pubmed.ncbi.nlm.nih.gov/37939186/?utm_…

It appears #NIAID will shutter the genome data base we all use daily. This strikes me as a significant mistake that may well endanger much of our global progress. British Society for Parasitology Aust Soc for Para ASTMH Trends in Parasitology ASP-Parasitologists parasitesrule PEERs in Parasitology (PiP)