🔥The 9th Round of Easy Loan, Earn $40 Reward is in progress❗️ ⏰ Promotion Period: January 15th - Feburary 15th, 2025 👉 Register now and check more details at gate.io/campaigns/358

Very excited to share our preprint demonstrating that common genetic variants contribute to variable expressivity in rare telomere biology disorders! Highlights below 1/ medrxiv.org/content/10.110…

Stem cell gene therapy can be used to treat diverse genetic diseases. How does a person's disease background affect gene-edited stem cell activity? A pleasure writing this Nature News & Views piece with Vijay Sankaran summarizing a fantastic study by Calabria & co nature.com/articles/d4158…

With controversy regarding the pseudoautosomal boundary, AJHG latest article's analyses of the available data consistently validate the original position, narrowing the location of the boundary to a 201-bp window: cell.com/ajhg/fulltext/… Page Lab #ASHG #HumanGenetics

Phenotypic variability in rare monogenic cases of telomere biology disorder with same genetic variant can be due to contribution of polygenic variation. Elegant study led by Vijay Sankaran Michael Poeschla in collaboration with Sharon A. Savage, M.D. and Us. medrxiv.org/content/10.110…

1/9 As part of my Ph.D. UT Southwestern Medical Center in MishraLab, I’m excited to share our Science Advances findings on how mtDNA mutations impact melanoma metastasis. science.org/doi/10.1126/sc…

Gene therapy is transforming how we treat genetic disorders, but what if mutations in more than 30 genes can cause similar symptoms? Now published in Cell Stem Cell (cell.com/cell-stem-cell…), we report the development of a universal gene therapy for Diamond Blackfan anemia. 1/n

My group's work dissecting the contribution of common variants to rare neurodevelopmental conditions is now out at nature.com/articles/s4158…. See this thread from co-first authors Qinqin Huang and Emilie Wigdor with a summary of the key findings.

What a fantastic talk by Travis Fleming at #ASH2024 befitting of his selection as the top graduate student abstract award. Really proud of you for the culmination of this impactful project describing how MECOM drives AML and providing clues about how we can target it.

Had a blast presenting our work yesterday at #ASH24! Feeling especially grateful for my mentors, colleagues and great friends who made this possible. A big thank you to Vijay Sankaran Richard Voit Michael Gundry Lara Wahlster and @mateusz_ant for their guidance and support.

So excited to see our NatureRevClinOncol review come together! Thrilled to share insights on T cell dynamics in neoadjuvant ICI-treated HNSCC patients. Huge thanks to Ravi Uppaluri, MDPhD for your incredible mentorship and for all you’re doing to change the field!

illuminating + surprising insights into polygenic disease risk in populations

Stem cell-like states confer poor outcomes in blood cancer—but what mechanisms drive this and how can they be therapeutically targeted? In our new preprint, we show how a single TF represses one enhancer to maintain a subset of high-risk leukemias: 🧵👇 biorxiv.org/content/10.110…

1 / Interested in how genetic variants influence complex traits? In our new preprint, we show that variant effects depend on the polygenic background in which they occur, and why it is critical to consider polygenic background when studying complex traits. biorxiv.org/content/10.110…

Excited that my first 1st authored paper from my PhD research has been published in Anesthesiology! We found that neural oscillations in the alpha band of frequencies (8-12 Hz) during anesthesia can predict the risk of postop mortality up to a year after surgery. 🧵 (1/3)

Delighted to share my PhD thesis work is now published in nature! This study tracks the journey of blood stem cells in aging mice, examining how the clonal dynamics of blood production change over time. A short 🧵1/n #aging #stemcells #clonalhematopoiesis nature.com/articles/s4158…

What protects individuals from developing blood cancers? Thrilled to share my work in Vijay Sankaran lab, describing inherited resilience protecting blood stem cells from clonal hematopoiesis by modifying RNA regulation. 🧵👇(1/n) biorxiv.org/content/10.110…

Beautiful work demonstrating how common variants modify the penetrance of rare variants in both children and adults with telomere biology disorders (TBDs). According to the liability threshold model, rare and common variants additively raise disease risk beyond a threshold,

Here we go again. Another company is selling embryo selection for intelligence. This time they claim to exclude the educational attainment predictor because of confounding. But the most recent data shows the intelligence predictor (which they use) is even more confounded!

Check out this fantastic plenary paper from Kai Tan Lab and colleagues in Blood Journal: tinyurl.com/mr9nzj3k Michael Poeschla and I had the privilege to write a commentary, "Getting to the root of high-risk leukemias" tinyurl.com/htf3e8d2

1/14 On behalf of the amazing team in Jonathan Weissman's Lab, we’re excited to share PEtracer (biorxiv.org/content/10.110…) a prime editing-based evolving lineage recorder compatible with both scRNA-seq and high-resolution imaging readouts in intact tissue. By applying PEtracer in a syngeneic mouse