The time to think and inquire are precious. Inquiring means to contemplate a problem without needing an immediate answer, to sit in the unknown long enough that different kinds of answers emerge. Important part of the process of discovery. nature.com/articles/d4158…

Chronic viral infection alters PD-1 locus subnuclear localization in cytotoxic CD8+ T cells: Cell Reports cell.com/cell-reports/f…

Excited that this heroic study on nuclear positioning of PD-1 locus in primary T cells from acute and chronic viral infection models is out!

Excited that we got the cover on a special issue of Biophysical Journal on Biophysics of Immune Cell Signaling with @JesusaCapera NDORMS Kennedy Institute of Rheumatology article on Dynamics and spatial organization of Kv1.3 at the immunological synapse... sciencedirect.com/science/articl…

Synaptic synergy of T cell receptor and interleukin 2 receptor in CD8+ T cells biorxiv.org/content/10.110…

Immuno-STATS create an immunological synapse to boost both the T cell receptor and IL-2 receptor signaling among the RIGHT T-cells!

Our latest paper "NaCl enhances CD8+ T cell effector functions in cancer immunotherapy" is now out Nature Immunology nature.com/articles/s4159… 🥳🎉🍾. A 🧵:

Reaching last day of an amazing event including three new The Royal Society Medal recipients!

Mechanical force matters in early T cell activation | PNAS pnas.org/doi/10.1073/pn…

T-cells with extra batteries!⚡️⚡️⚡️ Intercellular nanotube-mediated mitochondrial transfer enhances T cell metabolic fitness and antitumor efficacy: Cell cell.com/cell/fulltext/…

JCI - Microbial mimics supersize the pathogenic self-response jci.org/articles/view/…

A novel method for characterizing cell-cell interactions at single-cell resolution reveals unique signatures in blood T cell-monocyte complexes during infection biorxiv.org/content/10.110…

Interesting paper that builds on earlier work with DNA-CARs, linking DNA based interactions to TCR! Differential roles of kinetic on- and off-rates in T-cell receptor signal integration revealed with a modified Fab’-DNA ligand | PNAS pnas.org/doi/10.1073/pn…

Multi-omic characterisation of helper T cell extracellular vesicles that raise the alert! A resource for extracellular vesicles from activated CD4 T cells that relay pro-inflammatory signals biorxiv.org/content/10.110…

Solution structure and synaptic analyses reveal determinants of bispecific T cell engager potency biorxiv.org/content/10.110… When is flexibility not a good thing? When your a bispecific T cell engager! Latest update on TcE project University of Oxford Boehringer Ingelheim.

Activation-induced thrombospondin-4 works with thrombospondin-1 to build cytotoxic supramolecular attack particles | PNAS pnas.org/doi/10.1073/pn…

A weakly self reactive T cell receptor (magenta) can protect healthy tissue from a runaway CAR (green)! See how in: Engineering TCR-controlled fuzzy logic into CAR T cells enhances therapeutic specificity: Cell cell.com/cell/fulltext/…

Congratulations to Matthias Mann Matthias Mann Lab on election to the prestigious National Academy of Sciences! Your innovative proteomics research earns you this exclusive, elite honor. Your team couldn't be prouder! nasonline.org/news/2025-nas-…

We are delighted to announce that Professor Paul Kubes will deliver the Newton-Abraham Lecture 2025 on 19 May, 16:30-17:30. All members of the University of Oxford are welcome. More details here: talks.ox.ac.uk/talks/id/91d4b…

Selective requirement of glycosphingolipid synthesis for natural kille... sciencedirect.com/science/articl…