In case you are looking for an interesting/easy reading this weekend, how about some thoughts on in vitro human cell-based models cell.com/cell/abstract/… Cell Press Matthias Lutolf TAKEBE Takanori Laboratory

Out now cell.com/structure/full…. We show mechanisms of specificity on two look-alike pockets of Parkin for its activators (pNEDD8/pUb/pUbl), and loss of Parkin activity due to Parkinson’s disease mutation K211N. Dipti Ranjan lenka IISER Bhopal Department of Biotechnology SERB Structure

New paper on CHIP ubiquitin ligase from our lab 🎉🪱🔬

Congratulations, so well deserved! And especially proud of David Baker, the second graduate student from Randy Schekman's lab at UC Berkeley MCB to receive a Nobel.

PROTAC protein degraders to drug the undruggable enter phase 3 trials nature.com/articles/d4159…

Principles of paralog-specific degradation engaging the C-degron E3 KLHDC2, now out Springer Nature Nature Communications Awesome collaboration with Richard and Taosheng Chen labs. Structural Biology at St. Jude Children's Hospital Max Planck Institute of Biochemistry (MPIB) St. Jude Research #TPD #PROTAC #SchulmanLab rdcu.be/dWKpF

📚💡 ELiAH: the atlas of E3 ligases in human tissues for targeted protein degradation with reduced off-target effect academic.oup.com/database/artic… #TPD #Targeted_Protein_Degradation

Save the date! The annual Cancer Metabolism Symposium NYAS will be April 8, 2025 NYU Langone Health featuring another great lineup of speakers Kivanc Birsoy Christine Chio Marcia Haigis Andy Intlekofer Papagiannakopoulos Lab Rutter Lab Daniel Wahl Eileen P. White, PhD The Fuchs lab

Repeat after me: LAB WEBSITES MATTER! While it may seem like a nice-to-have... in today's world, it's a need-to-have. For you, your trainees, and your prospective team members. I couldn't have written this better myself: nature.com/articles/s4225…

Mechanism of degrader-targeted protein ubiquitinability Cool structural story science.org/doi/10.1126/sc…

🌳𝐍𝐖𝐇 𝐓𝐑𝐄𝐄𝐖𝐎𝐑𝐋𝐃 𝐈𝐍 𝐊𝐋🌳 ✨FREEBIES✨ 🌱 26 Oct 2024 🌱 Like & RT 🌱 120set (Random Keyring + PC) 🌱 Time & Place TBA 🌱 Dm for trade #NAMWOOHYUN #남우현 #TREEWORLDINKL #NAMWOOHYUNINKL #식목일4

Anyone has a clip of me in this at 1 minute I'd appreciate it!! Thank you Malaysian INSPIRITS for making me feel so welcome especially flying from Australia #NAMWOOHYUN #남우현 #NAMWOOHYUNINKL #NAMWOOHYUNINMY #TREEWORLDINKL #TREEWORLDINMY #INFINITE

Tools such as Rosetta and AlphaFold have redefined the protein-engineering landscape. But some problems remain out of reach — for now go.nature.com/3YT7zgN

Some important reminders for those presenting their metabolomics data. | The EMBO Journal embopress.org/doi/full/10.10…

Three people with severely impaired vision who received stem-cell transplants have experienced substantial improvements in their sight go.nature.com/3YHfP1N

What an elegant paper: intuitive yet unexpected, fiercely uncovering what many of us have suspected but clueless on how. nature.com/articles/s4158…

Getting the Numbers Right in Medicinal Chemistry - Ducho - ChemMedChem - Wiley Online Library …mistry-europe.onlinelibrary.wiley.com/doi/10.1002/cm…

A cholesterol metabolite against ferroptosis | Nature Cancer nature.com/articles/s4301…

The four basic kinds of scientific papers: 1. Noise (no claim and no evidence) 2. Resource (no claim but lots of data) 3. Conjecture (makes a claim, but no evidence) 4. Scientific advance (both makes a claim and presents evidence)

Diverse routes to mitophagy governed by ubiquitylation and mitochondrial import cell.com/trends/cell-bi…