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Dr. Totsune and colleagues present a conceptual argument against brain-first vs. body-first models of PD pathogenesis based on observed patterns seen with cardiac sympathetic denervation. loom.ly/xb18M0w

MDS’s Clinical Outcome Assessment Scientific Evaluation Committee found evidence supporting clinical use of 7 different tests of memory, language, reading, and visuospatial impairment among people with PD. MDS loom.ly/76qgyBw

A Bayesian network analysis of 85 RCTs for PD dyskinesia treatments identified 9 efficacious treatments for PD-dyskinesias, led by the #1 winner: GPi-DBS. loom.ly/Xq6aw0Q

A deep learning algorithm showed superior performance to human raters in differentiating spirals drawn by individuals with either dystonic tremor, essential tremor, essential tremor plus, Parkinson's disease, cerebellar ataxia, or healthy volunteers. loom.ly/dhQsUQE

Polygenic risk scores conferring a high risk for incident for ET in a large 30,000 person UK Biobank sample correlated with structural MRI changes in the brainstem, cerebellum, striatum, and motor thalamus. loom.ly/VQebxhA

PPMI data is evaluated to explore the validity of a new proposed staging system for neuronal alpha-synucleinopathies — including prodromal and manifest PD and DLB — called the NSD integrated staging system. loom.ly/T8VNh5M

A newly reported genetic alteration in mitochondrial ATP synthase (ATPase) is linked to a complex pediatric movement disorder phenotype. ATPase dysfunction may be pathogenically relevant for a broad group of Pediatric movement disorders. loom.ly/EHTE070

Long-read sequence technology has the potential to provide substantive pathogenic insights in many movement disorders current considered to be idiopathic. Drs. Wirth and colleagues shed light on how dystonia research might be a benefit from LRS approaches. loom.ly/JLkhBik

Strong concordance between an established rating scale (MDS-NMS) and its novel spinoff that can be self-completed by patients supports the MDS-NMS-Q as a valid and convenient questionnaire to assess non-motor symptom severity. #COA MDS loom.ly/G1WzJB0

Developments in genetics and cell biology over the past decade inspired an international panel of dystonia experts to propose an updated classification schema for use in research as well as clinical practice. MDS loom.ly/25czHcs

An fMRI study focusing on neurotransmitter networks showed correlations between PD fatigue and noradrenaline-enriched and glutamate-enriched functional connectivity in key regions, belonging to the sensorimotor, salience, and default mode network. loom.ly/fnR91Bo

A pharmaco-magnetoencephalography study identified beta-rhythmic responses of the cortical dopamine activation system as a key arbiter of inter-person variability in dopamine medication responsiveness in PD. loom.ly/2z3gESQ

Does CBD have a prodromal phase? Still an open question, but a fascinating case by Tai et al. showed progressive, asymmetric parietal atrophy on serial MRIs spanning a decade before the clinical diagnosis was made! loom.ly/VbRDHrY

No significant benefit of transcutaneous tibial nerve stimulation (1 Hz via Geko device) for overactive bladder in Parkinson’s disease, per phase II STRIPE trial. Maybe 1 Hz isn’t the sweet spot, and it’s worth exploring other settings/devices! loom.ly/K7VqFd4