As a medical school professor, I spoke yesterday at a #upenn session with President, Provost and others.

Here is what I said, a plea to American academia on behalf of Jewish students, staff and faculty.

#israel #HateSpeech #Zionism #AcademicTwitter

Thanks for all the feedback. Yes insulin resistance (IR) is the main driver behind LDL-c vs LDL-p discordance but also apoB vs LDL-p discordance ( see attached by the iconic Tom Dayspring)In the setting of IR, I recommend low carb diets. Keto may work but in susceptible patients…

LDL-p vs ApoB. Both outperform LDL-c and perhaps non-HDL-c in risk assessment especially on statins. Although, I am big fan of ApoB, I often prefer LDL-p because discordance from LDL-c is more evident. This is a good example in a patient with premature ASCVD on a statin.

We’ve met the enrollment target in our pivotal Phase 3 PREVAIL CVOT and, driven by strong interest globally, expect to randomize more than 9,000 patients with a history of ASCVD. bit.ly/3TTqpAs

podcasters.spotify.com/pod/show/ellio…
Listen to a incredible podcast of my primary care physician brother, Elliott interviewing my son, Preventive Cardiologist David. I am a very proud brother and father

My biotech TV interview about the history of New Amsterdam Pharma and Obicetrapib eur01.safelinks.protection.outlook.com/?url=https%3A%…

Patient will turn 100 in a few weeks. She has genetically confirmed FH and no clinical ASCVD. My search for resilience genes such as Klotho, IL-6, ACE, CETP or FOXO3 have not panned out. Other suggestions for protective genes?

In today's clinic, 52 yo with premature ASCVD with FH and very high Lp(a) controlled on Repatha and statin. He has two sons, oldest age 18 has LDL-C 60mg/dl and Lp(a) 84 nmol/L, the other age 12 with LDL-C of 124 mg/dl and Lp(a) 400 nmol/L. I started rosuvastatin 5 mg of the…

The Moral Deficiencies of a Liberal Education nytimes.com/2023/10/17/opi…
An articulate article by bioethicist Zeke Emanuel regarding the moral blindness of the student groups that justified the Hamas terrorist massacre. We need to educate but also hold these students accountable.

I have never before tweeted anything political but I am outraged by the the many college student groups ( for example 30 at Harvard) that support Hamas in their murder of over 1200 Israelis. As a biotech CEO, I pledge to never hire a person who supports Hamas. Anti-semitism…

Started my first patient on colchicine She is an ideal candidate: 69 yo female with non-obstructive LAD lesion with CPPD athropathy, LDL-C 53 HDL-C 92 but CRP 7 on a statin. Also scheduled a CLEERLY to monitor plaque changes over time. Still waiting for Ziltivekimab!

While our focus remains fixed on developing our #CETP inhibitor, obicetrapib, for patients at high risk of cardiovascular disease, we also know CETP loss-of-function mutations have been shown to protect against some forms of #Alzheimers disease (AD).

In our Phase 2a clinical…

A new indication for lowering TGs😀
Email from a patient:'my whole life, if there is a mosquito within a mile it finds me and bites me three times... This summer, with my triglycerides being , I've had maybe three bites all year. As long as I remember I was the kid who'd come…

Congratulations to Pallavi Pradeep for completing her Lipidology/Prevention Fellowship. I was blessed to have an another superb Fellow who excelled at patient care and developed into an amazing Lipidologist. She has a bright future ahead.

A first for me:Achilles tendon xanthoma and Charcot-Marie-Tooth syndrome features in the same foot. Looking forward to seeing my fellow lipid geeks at NLA

Our CEO, Michael Davidson MD, will present at the TD Cowen 43rd Annual Health Care Conference on Wednesday, March 8. We’ll have a live webcast of the presentation on our website. bit.ly/3KQv2Iz

Lipid geeks will love this case: 52 yo female with a strong family history of CHD, high CAC score (98th%)with a high HDL-C. On atorvastatin 10mg/EZE 10mg. SCARB1 + by GBH (SRB1 SNP). Attached is her NMR lipid profile. She has very high large HDL-P, the clue for SRB1 SNPs

March 10 is the deadline for applying to the fully funded Lipidology/Preventive Cardiology fellowship. In my biased opinion this is the best for this specialty.Do not take my word for it- please ask our formerFellows Lane Benes and Priya Palapatti and Pallavi Pradeep.