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APOE enthusiasts, If you have not already ....check out this incredible work published in Neuron from Na Zhao 👇👇👇

Central and peripheral tolerance thresholds that license CASPR2-antibody diseases are identified science.org/doi/10.1126/sc… Science Advances Mayo Florida AutoImmune Neurology Group

Great to have contributed to this wonderful study together with Kevin O'Connor, Mayo Florida AutoImmune Neurology Group and Bo Sun and many others🤗🤗

Congratulations Mayo Florida AutoImmune Neurology Group Bo Sun John soltys and team for their elegant study delineating breakdown in central and peripheral tolerance in CASPR2 antibody positive encephalitis!

Very nice study - well done…. We were all taught this assay didn’t generate false positives! Yet, I definitely have patients with AChR-Ab positivity and no clinical evidence of MG. So, I’m sure this study will help clinical practice👌

I can’t speak to your soul or stats but rewriting is the only way to improve the text. And it works! That’s how a good paper becomes excellent……

Mayo Florida AutoImmune Neurology Group Haha thanks Sarosh! Pleasure to work/re-write with you - would gladly do it again, hopefully some time soon! 🤓

Excellent work Sami

Amazing paper with the best pics! Look at these C3 tagged engulfed synapses - microglia caught in the act!!! Giovanni Di Liberto

Brilliant talk from basic immunology to very interesting data on how these principles apply to #celiac disease

Many congratulations to Professor Irani and all co-authors for winning the prestigious 2024 PNAS Cozzarelli Prize in Biomedical Science. 👏🧠 The winning paper was a collaboration between NDCN, The Department of Statistics, and the Mayo Clinic in Florida.

Read more 👇 ndcn.ox.ac.uk/news/oxford-le…

The inaugural #Mayo #clinic Autoimmune Neurology conference Mayo Clinic Neuro Mayo Clinic Dr Gregory Day speaking about trials and treatments in #autoimmune #encephalitis

This is very useful. Question is how we now improve the models? Ideas?

Thanks for highlighting this work. The patients we are seeing continue to teach us so much!

Mayo Florida AutoImmune Neurology Group Thank you for sharing such an insightful case. We're all learning thanks to your work.

Beware commercial tissue based assays (TBAs) to detect cell surface autoantibodies in neurology. TBAs are often used as screening tests and are reader dependent. Bottom line: please think clinically when diagnosing autoimmune neurological syndromes pubmed.ncbi.nlm.nih.gov/40393020/

My Editorial is out on actively immunised mouse model in NMDAR. Hope you enjoy! academic.oup.com/brain/article/…

Heard it before??? It’s not stridor but an inspiratory noise which myself and Divyanshu Dubey observed in patients with #iglon5 #antibodies