📣Two open positions (postdoc and PhD) in our group at Aarhus Uni, Denmark to explore genetic innovation in the regulation of animal germline genomes. RTs/sharing highly appreciated 🙏. More about our research and philosophy here (email/DM also 👍): mbg.au.dk/pan 1/3

Check out this powerful new app to visualize protein expression during differentiation of iPSC neurons - developed by James Hawrot, Andy Qi, Mike Nalls, and Faraz Faghri at NIH and DTI, leveraging datasets from our recent iNDI pre-print. niacard.shinyapps.io/i3Neuron/

I'm in Dundee at last! I'm also interviewing postdocs to explore the roles of ERphagy. ppu.mrc.ac.uk/careers/recrui… Deadline approaching soon!

Bode Group adventures in autophagy: We report the presence of an unknown LIR motif in human ATG3 discovered using a combination of new activity-based probes, computational modeling and x-ray crystallography. The LIR motif is crucial for LC3-lipidation. biorxiv.org/content/10.110…

Please RT! I'm proud to tell everyone that the iPSC Neurodegenerative Disease Initiative #iNDI that I've been leading with @wardm50 is a physical entity as of today so let me explain why this is a huge deal: jax.org/jax-mice-and-s…

Announcement #2. The Querques lab will open soon at Max Perutz Labs Vienna and we have 2 #PhD positions available to study the mechanisms and applications of mobile DNA using #CryoEM and #Biotechnology. If you are interested, reach out to us and apply via Vienna BioCenter Scientific Training! RT appreciated.

The Austrian Academy of Sciences is hiring a Scientific Director for IMBA. Please RT. ➡️ Deadline for Applications: October 31, 2022 ➡️ APPLY: bit.ly/3RANMfA Vienna BioCenter Austrian Academy of Sciences #director #jobs #research #hiring

If you agree that ERC should remove their academic age limits on ERC grants - please Sign this Petition! Please also RT: #EDI #science #EuropeanScience #ERCgrant chng.it/zvm4fDmFdj via Change.org UK

My lab is hiring a CRUK-funded postdoc to work on ERphagy in cancer progression! ppu.mrc.ac.uk/careers/recrui… We are looking for candidates with cancer/cell biology expertise. There is also another upcoming postdoc position to work more broadly on other aspects of ER QC (1/2)

Very happy to share work from my PhD in the Bode Group. We report the presence of an unknown LIR motif in human ATG3 discovered using a combination of new activity-based probes, modeling and x-ray crystallography. tinyurl.com/mrxtmsv6 ACS Central Science

I'm looking for a bioinformatician to join my group! Searching for someone collaborative & self-motivated with expertise in NGS analysis.For example, functional genomics, single-cell, splicing, RNA binding, lineage barcoding, ChIP-seq. Apply at jobs.ethz.ch/job/view/JOPG_…

July 6th, 12pm EST Bernat Crosas Bernat Crosas (IBMB) 26S proteasome PROTACs. Matthias Muhar (ETH Zürich) C-terminal chemical degron.

Cells degrade unfolded proteins. But do they also check for chemical damage? We found that a C-terminal amide is completely sufficient for degradation by an SCF/FBXO31 ligase complex! With Bode Group Matthias Muhar Jakob Farnung. biorxiv.org/content/10.110… 🧵

Every peptide chemist will tell you that C-terminal amides are more stable than C-terminal acids. It turns out that is completely wrong for intracellular proteins! A fantastic collaboration with Jacob Corn, Matthias Muhar, Jakob Farnung

Genetic interactions reveal unexpected biology and can lead to novel therapeutics (e.g. #Olaparib). In a new preprint, John Fielder and Sebastian Siegner w/ Cejka Lab comprehensively unravel *all* genetic interactions in the human DNA damage response! biorxiv.org/content/10.110… 🧵

Want to hunt down the cullin-RING E3 #ubiquitin ligases involved in your favorite pathway or #DegraderDrug? Exited that our story on probing active (neddylated) #CRL E3 complexes using conformation specific probes is out now! nature.com/articles/s4158…

Have you ever wondered how embryos coordinate translation? Our new preprint shows that 5′ UTRs confer translational dynamics during early #zebrafish embryogenesis! 🐟biorxiv.org/content/10.110… Thread 1/6

There’s a frequent perception among recent entrants to drug discovery world that if we could just find drug candidates faster, this will be a useful accelerant to the overall process. The issue is: this thinking is mostly (but not entirely) incorrect. 🧵 1/

Woohoo! Really excited to present our discovery that stress response silencing is an active and regulated process that is tightly linked to neurodegenerative disease! nature UC Berkeley MCB UC Berkeley #MolecularTherapeutics nature.com/articles/s4158…

Congratulations to Madalena Madeira Reimão Pinto Madalena Pinto and Sandhya Manohar Sandhya Manohar with the 1st and 2nd prizes at PIOT Final! Sponsors: Cells MDPI, Medical Sciences, Nikon, New England Biolabs, Biochemical Society Transactions Portland Press #BiochemSocTrans