Please join our The North West Genomic Laboratory Hub webinar to launch WGS for CUP patients in the North West. We are eager to link in with the CUP community to encourage uptake of testing. Discussion on challenges and opportunities led by Dr Natalie Cook Natalie Cook 💙 Greater Manchester Cancer Alliance Cheshire and Merseyside Cancer Alliance Lancashire and South Cumbria Cancer Alliance

Please take a look at our new #Genomics in Practice newsletter. This first edition has been produced for colleagues working within #GeneralPractice but we will be producing future editions for #nursing, #midwifery, and #pharmacy colleagues. bit.ly/3LpYId3

#ASCO22 Dr. Matthew Krebs presents update on CHRYSALIS from amivantamab in #MET exon 14 skip mutation NSCLC. While amivantamab is approved for #EGFRex20, this bispecific targets both EGFR and MET with an even higher affinity for MET (40 pM) than EGFR (1.4 nM).

Clearly ctDNA is a popular topic at this years #ASCO22. Packed room for our discussions on ctDNA in GI cancers. Lots of great questions too! Thanks for the invite to talk and great to meet Jeanne Tie- can’t wait for the DYNAMIC trial result tomorrow! ECMC Network (@ecmc-uk.bsky.social) Division of Cancer Sciences Manchester Cancer Research Centre

Thank you Stephen V Liu, MD and thank you to the ASCO Scientific Committee #ASCO22 for selecting us for oral presentation. Updated data from the CHRYSALIS study for Amivantamab in MetEx14 skipping NSCLC

##ASCO22 Is over! #LCSM It was a great, to recap data presented on the EGFR-positive disease, with Matthew Krebs Nicolas Girard & Joshua Sabari, MD for the post-ASCO OME forum. New evidences & results in the fields are really promising (post -Osi resistant & exon20ins disease)

Congrats to the organising committee for a fantastic UK Oncology Forum meeting #OF22 Oncology Forum UK and thank you for the privilege to deliver the opening keynote. Enjoyed all the talks and Question Time! Look forward to next year in Brighton

Toby working hard today in the school allotment for Open Gardens event next week ⁦PTA Eco helpers - Brookburn Primary⁩ having fun 🙂

Gilberto de Lima Lopes, Jr, MD, MBA, and Matthew Krebs, PhD, on NSCLC: Updated Results With Amivantamab-vmjw ascopost.com/videos/2022-as… #ASCO22 #LCSM #lungcancer #immunotherapy gilberto lopes Matthew Krebs The University of Manchester

Very sad 😢 to say goodbye to our current ECMT fellows Prerana Huddar Angelos Angelakas Neal Ramchander Kyrillus Shohdy, MD and Bill (who somehow is not on Twitter!) It has been great working with you all, wishing you all the best for the rest of your training. See you on call! Manchester ECMC

Circulating Tumor DNA in the Treatment of Patients With Cancer ja.ma/3CWwnbj via JAMA Oncology part of JAMA Network. Proud to be part of this expert collaboration Christian Rolfo Umberto Malapelle Luis Paz-Ares FabriceAndre Division of Cancer Sciences The North West Genomic Laboratory Hub NHS Genomic Medicine Service

How to read an #NGS report in #liquidbiopsy form our JAMA Oncology paper: #ctDNA in the Treatment of Patients With Cancer ja.ma/3DQ7v6I via JAMA Network Christian Rolfo FabriceAndre @Matthewkrebs Paz-Ares's Lab International Society of Liquid Biopsy

And finally we meet in #Atlanta after one year working on JAMA Oncology paper Practical Considerations for the Use of Circulating Tumor DNA in the Treatment of Patients With Cancer: pubmed.ncbi.nlm.nih.gov/36264554/ Matthew Krebs Christian Rolfo

Congratulations Ana and the entire TARGET National Consortium. A fantastic collaboration to enhance precision medicine opportunities with liquid biopsy for patients in the UK ECMC Network (@ecmc-uk.bsky.social) NHS Genomic Medicine Service The North West Genomic Laboratory Hub Division of Cancer Sciences The Christie Charity Sir Bobby Robson Foundation

Fantastic news! We have completed enrolment to all 5 arms of the MiST trial & recruitment is now closed! Huge thanks to all those involved Dean Fennell FRCP University of Leicester Mesothelioma UK @leicresearch @matthewGKrebs The Christie NHS @alastairGreyst2 Sir Bobby Robson Cancer Trials Research Centre University Hospital Southampton 💙 @wythenshaweHosp

Fantastic Manchester based senior clinical fellow opportunities in early phase cancer clinical trials. Come and join us Manchester ECMC ECMC Network (@ecmc-uk.bsky.social) Manchester Cancer Research Centre Careers at The Christie Matthew Krebs Dr Donna Graham 👉🏻 beta.jobs.nhs.uk/candidate/joba…

Congratulations to the entire DETERMINE team and all our collaborators on this fantastic achievement - very proud Division of Cancer Sciences Cancer Research UK The Royal Marsden NHS Foundation Trust Uni of Birmingham Roche Novartis ECMC Network (@ecmc-uk.bsky.social) Bionow Entrust Resource Solutions The University of Manchester The Christie NHS NHS England

The DETERMINE study is designed to evaluate licensed treatments in new indications such as this. There is a treatment arm for HER2 positive patients. We are actively seeking new pharma partners for other medicines cancerresearchuk.org/funding-for-re…. BBC News (UK) The University of Manchester Science and Innovation at Cancer Research UK

Results from a phase I study of the CDK7-inhibitor samuraciclib: dose escalation and expansion cohorts in patients with advanced breast cancer. nature.com/articles/s4146… #CancerResearch Cancer at Nature Portfolio Surgery and Cancer Matthew Krebs Division of Cancer Sciences

Exciting PhD opportunity exploring non-genomic drivers of NSCLC with training in data integration for multi-omic analyses. Co-supervised by Medicines Discovery Catapult and myself in the experimental cancer medicine team NIHR Manchester Biomedical Research Centre Division of Cancer Sciences The Christie NHS