Congrats to my former ⁦Harvard University⁩ bandmate ⁦Carolyn Bertozzi⁩ on her ⁦The Nobel Prize⁩ in chemistry! We won the Ivy League Battle of the Bands in 1986 with our rockin’ group ‘Bored Of Education’, with her on keyboards & me in spandex. news.stanford.edu/2022/10/05/car…

Nature’s survey of PhD students & postgraduates this year survey should set loud alarm bells ringing - PhD scholars & early-career researchers need to be paid properly; the cost-of-living crisis is a fundamental threat to future generation of researchers nature.com/articles/d4158…

Spinny boi, go! 😄

When I first heard Mangyu Choe and Denis Titov present on this project, my metabolic mind was blown! Incredible work! Congrats!

1980s PBS after school special-ass calcium wave

We have posted an updated version of our study showing that Warburg Effect-like metabolism in mammalian cells, yeast and bacteria is the result of optimization of energy metabolism to achieve max ATP production rate under diverse conditions. biorxiv.org/content/10.110…

Rejection of your paper or grant has NO relevance to the opinion of #research community. It is nothing but the opinion of one person. Several examples: 1. The first paper on graphene was rejected from Nature because “it did not constitute a sufficient scientific advance”.

A late update, but mine and Justin’s paper was published in eLife - the journal last month! We show, in both intact and permeabilized cells, that calcium influx upon plasma membrane wounding triggers #exosome secretion and that this process is mediated by Annexin A6! doi.org/10.7554/eLife.…

Excited to share updated preprint by Mangyu Choe showing that, contrary to textbook view, the role of allosteric regulation of glycolysis is not to control rate but to maintain ATP levels by preventing a futile cycle between upper and lower glycolysis. 🧵biorxiv.org/content/10.110…

Happy to share that our paper is finally out today cell.com/immunity/fullt….

New preprint from our lab led by Mangyu Choe where we develop a genetically encoded tool for manipulation of ΔΨm and use it to show that uncouplers have major side effects and ISR in response to ATP synthase dysfunction is driven by ΔΨm. A 🧵... 1/8 biorxiv.org/content/10.110…

New preprint w/ Ana Paula Arruda! Tour de force from grad student extraordinaire Alyssa Mathiowetz! >20 CRISPR screens enabled the discovery of a key role for CLCC1 in hepatic neutral lipid flux and nuclear pore complex assembly. Many surprises! #LipidDroplets 1/3 biorxiv.org/content/10.110…

The final form of our manuscript on the Warburg Effect is out today in PNAS! Check it out!

A new study led by Matt Kukurugya and UC Berkeley Metabolic Biology professor Denis Titov provides compelling insight into why cancer cells choose a seemingly inefficient way of producing energy, even when higher-yielding alternatives are available. nature.berkeley.edu/news/2024/11/c…

Beautiful microscopy images, calorie restricted worms, ~60% lifespan extension! What more could you want!!!

Excited to share our lab's new paper led by Mangyu Choe where we co-opt UCP as a genetically encoded tool for manipulation of mitochondrial membrane potential. We use this to demonstrate that high ΔΨm drives integrative stress response in response ATP synthase inhibition... 1/2

An elegant model: - TF binding events on nucleosome-free DNA are independent. - Yet, the activation domains of TFs recruit cofactors that destabilize nucleosomes, resulting in cooperative TF binding. - Average TF occupancy linearly determines promoter activity