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Original Article Serum amyloid A1-Induced intrahepatic regulatory T cell dysfunction drives autoimmune hepatitis progression Wang et al. #LiverX tinyurl.com/4xtrm86y

We need more such datasets. I believe that reaching some hundreds of tissue samples for sc-eQTL discovery will be transformative for understanding genetic predisposition to human disease. 🔗link to study: nature.com/articles/s4158… 📊sc-eQTL summ stats: zenodo.org/records/145864…

Original Article Tumor microenvironment heterogeneity and progression mechanisms in intrahepatic cholangiocarcinoma: A study based on single-cell and spatial transcriptomic sequencing Li et al. #LiverX tinyurl.com/vev2xepx

A Translating Immunology article re-evaluates B cell depletion strategies, providing an alternative explanation for why CD19 depletion may be effective at achieving complete and durable remission in autoantibody-positive autoimmune diseases. Read more: ow.ly/3XFy50WbZkr

Original Article Refinement of histologic subtypes and identification of biomarkers linked to unfavorable prognosis in cholangiocarcinoma: The ENSCCA registries’ framework for digital twin advancement Carpino et al. #LiverX tinyurl.com/4udc46df

MetaNet: a scalable and integrated tool for reproducible omics network analysis biorxiv.org/content/10.110…

GeneRanger is a web-server application that provides access to processed data about the expression of human genes and proteins across human cell types, tissues, and cell lines from several atlases. generanger.maayanlab.cloud/en/gene/A1CF?d…

We are all somatic mutation mosaics. "There are trillions of cells in a human body and so the total number of somatic mutations acquired in a single individual may well exceed quadrillions, millions of times the size of the human genome." nature nature.com/articles/s4158…

Cell-type deconvolution methods for spatial transcriptomics. #SpatialTranscriptomics #CellTypeDeconvolution #Bioinformatics #Genomics Nature Reviews Genetics nature.com/articles/s4157…

Utilizing a prospective pre-disease cohort, Research Letter reveals that early #Epstein-Barr virus exposure could significantly increase the risk of developing #CrohnsDisease. Learn more at ow.ly/MHSJ50WlMC4 #EBV #IBD

Temporal and spatial omics technologies for 4D profiling nature.com/articles/s4159…

A multimodal conversational agent for DNA, RNA and protein tasks nature.com/articles/s4225… 🧬🖥️🧪 huggingface.co/InstaDeepAI/Ch…

This is a wonderful review in Trends in Cancer on extrachromosomal DNA (ecDNA) from the best in the field, & it’s #OpenAccess. Extrachromosomal DNA: shaping the evolutionary dynamics of cancer cell.com/trends/cancer/… Mischel Lab Charles Swanton Benjamin Werner

Spatial Transcript Omics DataBase (STOmics DB) is a comprehensive repository of literature and Datasets related to spatial transcriptomics topics, and provides convenient tools for Data analysis, search and visualization. db.cngb.org/stomics/

Pan-cancer human brain metastases atlas at single-cell resolution dlvr.it/TLw4ZN

BugBuster: a novel automatic and reproducible [Nextflow] workflow for metagenomic data analysis academic.oup.com/bioinformatics… 🧬🖥️🧪 github.com/gene2dis/BugBu…

Brain metastasis: From etiology to ecotypes dlvr.it/TLxJTF

2⃣Correlations of the CSF-plasma proteome across the cognitive aging spectrum The study describes changes in CSF to plasma ratios for 2,304 proteins in paired samples from 2,171 individuals. It found age to be associated mainly with increases in CSF protein levels relative to

A unified pan-cancer proteome atlas dlvr.it/TM2Vvh

PEANUT: Pathway Enrichment Analysis through Network Utilization. #PathwayEnrichment #Bioinformatics academic.oup.com/bioinformatics…