Here is the first paper, which shows that variants in only 13 influenza susceptibility candidate genes that govern TLR3- and IRF7-dependent production of type I IFNs account for at least 3.5% of critical cases of #COVID19 science.sciencemag.org/content/early/… Science Magazine

Here is the other paper, which shows that neutralizing auto-Abs to type I IFNs account for at least 10% of critical cases of #COVID19, even in a greater proportion in men: an auto-immune phenocopy of the corresponding inborn errors science.sciencemag.org/content/early/… Science Magazine

Two papers published online this week in Science, about hidden immune weakness in gravely ill #COVID19 patients, explain nearly 14% of severe cases of the disease—a “remarkable” development. fcld.ly/iu9na6t

Garvan’s Prof Stuart Tangye, in collaboration with KU Leuven's Prof Isabelle Meyts, has co-led a multi-centre international consortium to assess the severity of #COVID-19 in individuals with inborn errors of immunity. ow.ly/eSIH50BKum8

Rogue Antibodies and Gene Mutations Explain Some Cases of Severe COVID-19 – NIH Director's Blog directorsblog.nih.gov/2020/10/06/rog…

Just how sick we get from #COVID19 depends on genetic variations, including ones that sabotage immune molecules called interferons. Check out this Knowable Magazine piece from tim vernimmen on the Casanova Lab's work to better understand why: knowablemagazine.org/article/health…

No se lo pierdan/ don’t miss it !!! Casanova Lab Grupo IDP JMF @AriasAAS

Now Live: facebook.com/watch/live/?v=…

Officially published too! Again, TLR3, type I IFN, and the central nervous system. :)

Our new work about Gata2 defiency & mycobacterial infectious diseases is online at J Clin Imm rdcu.be/cdic4 Excellent international collaboration with many friends in the world.

Genetic, Immunological, and Clinical Features of 32 Patients with Autosomal Recessive STAT1 Deficiency pubmed.ncbi.nlm.nih.gov/34183371/

Congratulations to Tom Le Voyer for his important contribution in the first international cohort of patients with autosomal recessive STAT1 deficiency. Thanks so much to all collaborators in the world. pubmed.ncbi.nlm.nih.gov/34183371/

Happy to share my first PhD paper investigating the mechanism by which human PKCD deficiency underlies susceptibility to infectious disease. Published today in Journal of Experimental Medicine bit.ly/36K8QKV Casanova Lab

Happy and honored to be part of this great research!!! Huge effort not only of people like me were doing experiments but also from physicians and patients around the world.

Second great research from our group with the help of many scientists, physicians and patients!!!

Congratulations Jean-Laurent Casanova Lab, very well deserved!!!!

Great review!!!

Paul Bastard of the Casanova Lab and Inserm has won the Michelson Philanthropies & Science Magazine Prize for Immunology for revealing factors that underlie varied susceptibilities to #COVID19. Congratulations! Learn more about his work here: science.org/doi/10.1126/sc…

1/ Free registration is still open for this week's 29th Annual Henry Kunkel Society virtual meeting on "Innate Immunity: from basic biology to human disease" chaired by BogunovicLab of Icahn School of Medicine at Mount Sinai, and in partnership with Journal of Experimental Medicine! Register here: rocku.zoom.us/webinar/regist…

What is the cause of RARE cases of myocarditis following COVID-19 mRNA vaccination? Read our hypothesis & our plan to answer the Q: rdcu.be/cW7IX Thankful to work with a great team of scientists & physicians from all over the world. Details in 🧵