We desperately need biomarkers in RCC @TurajlicLab provides a stellar roadmap forward If you missed this talk/session, I encourage you to find it on the #GU25 app/website. An absolute must-watch for anyone in the field! ASCO OncoAlert

The future of biomarkers in RCC is challenging‼️#GU25 Need for: 📊 Sample & Data Harmonisation 🔴 Overcome pervasive heterogeneity 🩸Incorporation of dynamic measures 🧠 Collaborative efforts ➡️ Generation of multimodal biomarker signatures 🧑‍💻: manifest-io.org.uk

Delighted to welcome Lord Vallance & Baroness Merron Department for Science, Innovation and Technology Department of Health and Social Care Productive roundtable discussions, highlighting: 📍MANIFEST IO's roadmap to IO biomarker discovery 🗺️UK-wide cross-institution collaboration 🧬Investing in emerging tech 🖥️Data & assay harmonisation

Delighted to present our Turajlic Lab @ The Crick work on utilising AI-assisted high dimensional PBMC profiling to predict IO response and toxicity as a late breaking poster and talk at #AACRIO2025 today. Great collaboration with our partners at #IMUBiosciences as part of MANIFEST IO

🚨First output from the MANIFEST IO platform‼️ 🩸PBMC derived immune signatures can predict ICI response & tox! 🧑‍💻 Hugely collaborative effort led by Max Emmerich @TurajlicLab in conjunction with #IMUBiosciences 📍Watch this space for multimodal composite biomarkers

A great talk from Dr Pippa Corrie about the MANIFEST project. Thank you Dr Corrie for an insightful presentation.

🚨Opportunity to join the MANIFEST IO team ‼️ We’re looking for: 💻 A Talented ML Engineer To: 💊Deliver on integrated immune-oncology biomarker signatures 📍The Crick Turajlic Lab @ The Crick 🧑‍💻manifest-io.org.uk Link 👇: crick.wd3.myworkdayjobs.com/External/job/L…

James Jones (CRUK Cambridge Institute) presents amazing work on “Cytokine profiling in kidney cancer translational studies” 🏥

Up next Dominic Rothwell (CRUK National Biomarker Centre) presents “cfDNA methylation profiling as a precision medicine biomarker in cancer” 🧬🔍

Up next, Santiago Zelenay (CRUK Manchester Institute) presents his work on setting up a “Patient Derived Tumour Fragment platform” 🧫

Ajitha Rajan (The University of Edinburgh) joins us over the web to present on “Multimodal Data Integration” 🔬🖥️

Our keynote speaker Elana (Univ. of Maryland) presenting some fantastic work on “Modelling the TME of clinical trials with virtual cells” 🦠🖥️

Fantastic to see the first iteration of data from the EXACT study, characterising dynamic changes in peripheral immune subsets as predictors of ICI response and toxicity! 🩸💊🏥 Great presentation from Max Emmerich in collaboration with the team at IMU Biosciences!

A thought-provoking first MANIFEST IO consortium meeting 🧠! 📈👩‍💻 Spotlighting emerging data/technologies across the consortium! 🧬🏥Highlighting the critical importance of cross-collaboration and harmonisation across consortium partners! Thank you to all in attendance!

Fantastic inaugural MANIFEST IO consortium meeting! 🧑‍🔬>100 consortium members in attendance 🧑🏾‍💻Critical discussions re: cross-collaboration & data harmonisation 🏥Key focus on improving patient outcomes Huge credit to @JuliaNeedham_ @TurajlicLab (& team) & Jon Lim, MRCP PhD

Delighted to share our vision for the MANIFEST IO consortium in a recent editorial in Cancer Discovery 📝 Enquires re: collaboration opportunities pls reach out to us at: 📧 [email protected]

In Focus: MANIFEST: Multiomic Platform for Cancer #Immunotherapy brnw.ch/21wSFZq By Jon Lim, MRCP PhD, Zayd Tippu, Turajlic Lab @ The Crick, and colleagues on behalf of the MANIFEST consortium at MANIFEST IO, The University of Manchester, The Christie NHS, The Francis Crick Institute, The Royal Marsden NHS Foundation Trust

🎙️ImmunoBuddies Podcast – Manifest - the final part! Endless Potential, The Future of Predictive Biomarkers for Treatment Response and Toxicity with Dr.Zayd Tippu from The Francis Crick Institute. Join us as Dr. Zayd Tippu explores the limitless potential of predictive biomarkers—what's next,

Delighted to have been able to join Ricky Frazer & Anna Olsson-Brown for my pod debut 🎧 Opportunity to chat all things MANIFEST IO: 📍UK wide collaborative effort 📈Large scale data/sample & assay harmonisation ➡️ Integrated predictive IO biomarkers 👨‍💻manifest-io.org.uk

Team MANIFEST presenting 10x Genomics Discovery Symposium! 📈Highlighting novel spatial methods to characterise TiME determinants of ICI response 🧬 Critically dependent on collaborative efforts through the MANIFEST IO consortium ‼️