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A study suggests that prepandemic and SARS-CoV-2–negative cases that are indistinguishable from MIS-C are characterized by Vβ21.3+ T-cell expansion and may be triggered by other pathogens. Read the full correspondence: nej.md/49SwOTT

Thrilled to share our paper in NEJM on pre-COVID and SARS-CoV-2 negative MIS-C. This condition predates the pandemic but was incredibly rare and often misdiagnosed as Kawasaki Disease Shock Syndrome or Toxic Shock Syndrome without identified bacteria nej.md/49SwOTT 🧵

Sometimes groundbreaking research means demonstrating there nothing new but we missed it before! 'Old' Coronaviruses were triggering MIS-C in children before #SARSCoV2 👇👇👇 #pandemicpreparedness

Beautiful work from Belot Alexandre and team on MIS-C assigned to the pre-COVID area, including TCR Vb21.3 expansion! x.com/NEJM/status/17…

COVID-19 : le syndrome inflammatoire multi-systémique de l’enfant (PIMS) existait avant la pandémie teamhcl.chu-lyon.fr/covid-19-le-sy… HCL - Hospices Civils de Lyon CIRI Lyon (Université Lyon 1 @ENSdeLyon Inserm Auvergne-Rhône-Alpes CNRS Rhône Auvergne)

MIS-C existed pre-COVID? See this report from Belot Alexandre and colleagues. Time to re-think about Kawasaki disease and other post-infectious inflammatory conditions.

Correspondence: Pre–Covid-19, SARS-CoV-2–Negative Multisystem Inflammatory Syndrome in Children nej.md/49SwOTT #Pediatrics

Fantastic research day at Rhumatopedies 2023, the 10th edition that welcome in Lyon many talented young researchers in the field of Pediatric Immunology/rheumatology & Incredible talk of our guest Petter Brodin! Thanks for coming

History of a success: exciting science, friendship and Cuisine Lyonnaise. Petter Brodin #Rhumatopedies2023

Fascinating paper on pre-covid possible MIS-C with implications for understanding pathogenesis. Congrats Alex Belot and team. Pre–Covid-19, SARS-CoV-2–Negative Multisystem Inflammatory Syndrome in Children | NEJM nejm.org/doi/full/10.10…

🔬 🌐 Check out our comment on drug development in ultra-rare diseases in The Lancet, spotlighting promising results of a new C5 inhibitor via SC route for CD55 deficiency. 🩺 #RareDiseases #MedicalBreakthrough"thelancet.com/journals/lance… ⤵️

❔Quel est le lien entre cancer et système immunitaire ? Thierry Walzer, directeur de recherche Inserm et chef de l'équipe LYACTS-CIRI, l'explique dans l'émission #TêtesChercheuses, dont voici un extrait 👇 Retrouvez l'émission complète ici ➡ youtube.com/watch?v=B2N913…

Ce 29 février, c'est le #RareDiseaseDay2024. Au CIRI, les équipes I2BA (T. Henry) et LYACTS (T. Walzer) étudient des maladies rares auto-immunes et auto-inflammatoires. Un grand merci aux cliniciens qui font avancer la recherche, et aux patient/es !

Excellent review on monogenic SLE: link.springer.com/article/10.100…

Mendelian causes of autoimmunity -> the #lupus phenotype! A fascinating (disease) syndrome #IEI, #RareDisease #Genetics with Maud Tusseau Plassart Samira Jade Cognard @SarahBenezech Liliane Khoryati @Seb_Viel @FRLab1 LYACTS-CIRI, Still so much left to uncover.

6 novel monoallelic PTPN2 mutations in pediatric lupus and Evans syndrome that cause T cell hyperproliferation and high inflammatory cytokines Journal of Experimental Medicine doi.org/10.1084/jem.20… @MACattackLab comment doi.org/10.1084/jem.20… Belot Alexandre @FRLab1 #Mathieu

Honored to have been part of this beautiful collaboration with @JEANPIERRMarie from @FRLab1 team in Institut Imagine for my very first steps in the lab, thanks to LYACTS-CIRI, Maud Tusseau Belot Alexandre and Anne-Laure Mathieu ! ✨´

Thrilled to share our work on PTPN2 mutations in autoimmunity. Congratulations to all authors on this beautiful study! A great collaborative effort between @FRLab1 team at Institut Imagine and Belot Alexandre's team at LYACTS-CIRI CIRI Lyon Jade Cognard Maud Tusseau AL Mathieu

📢 SAVE THE DATE! RHUMATOPEDIES 2024 is coming 📅Wednesday 4th December 2024 📌 University of Lyon, 69007 LYON 👨‍⚕️ Lecture by Prof. Daniel Kastner, MD, PhD 📝 Registration: lnkd.in/emX8Pn8T 📰 Scientific Programme below