Very happy to have our latest work on how IκBα regulates stemness independently from NF-κB. It has been a terrific collaborative work led by Lluís Espinosa (Bigas/Espinosa Lab) and Daniel Alvarez-Villanueva (Dani Alvarez Villanueva) HMar Research Institute #nfkb #ikb #inflammation #stemcells

We’re Blainey Lab sharing a major update to CROPseq-multi, our versatile system for CRISPR screens that is compatible with individual and combinatorial perturbations, diverse SpCas9-based technologies, and multiple high-content, single-cell readouts. biorxiv.org/content/10.110…

Thrilled to share with you the latest work from my PhD in Bigas/Espinosa Lab HMar Research Institute Josep Carreras Leukaemia Research Institute (IJC) published in Blood Journals Portfolio We’ve programmed blood stem cells from PSCs using CRISPRa screen and found a new “bloody” cocktail #CRISPR #HSCs #StemCells kwnsfk27.r.eu-west-1.awstrack.me/L0/https:%2F%2…

Thanks everyone involved in the work (Gayathri M Kartha, Arnau, Jessica, Patricia). Special thanks also to our amazing team of collaborators: Mercedes Barrero Asencio PayerLab Menendez Lab It’s been a pleasure to work with you all!!

Proteomic aging signatures across mouse organs and life stages embopress.org/doi/full/10.10…

A cocktail of 7 genes activated at the mesodermal stage induces mouse embryonic stem cell–derived multilineage repopulation and self-renewal. ow.ly/zCkp50WsTti #hematopoiesisandstemcells

Optical pooled screening is enhanced by amplification of barcodes before in situ sequencing go.nature.com/3ZVzqOi rdcu.be/exfh0

How stem cells respond to infection, inflammation and ageing bit.ly/4lINKS2

New online! Methods and applications of in vivo CRISPR screening bit.ly/40BAAy0

Glad to share our latest Signal Transduction and Targeted Therapy (STTT) review on #cancer #stemness and #epigenetic. Kudos to Claudia Galassi, PhD for taking the lead, not possible w/o critical input from Ilio Vitale #offttwitter and Manel Esteller Josep Carreras Leukaemia Research Institute (IJC) Fox Chase Cancer Center Free at rdcu.be/eyLAz

Beautiful study that combines 3D culture (mouse gastruloids) with CROP-seq Regulation of mRNA polyadenylation governs mammalian body plan formation in gastruloids | BiorXiv #Gastruloids #CRISPR biorxiv.org/content/10.110…

ProDomino is a machine learning-based method that predicts domain insertion sites and helps guide the engineering of functional multi-domain proteins. nature.com/articles/s4159…

I’m curious to know how this model is different from the one published by Samantha Morris more than two years ago? nature.com/articles/s4158…

#NewProfilePic

Now online! Composite transposons with bivalent histone marks function as RNA-dependent enhancers in cell fate regulation dlvr.it/TMLMLj

Excited to see this published with additional data following our preprint a while back. Cool combination (in our biased view) of controlled TF expression and machine learning to decode chromatin sensitivity. sciencedirect.com/science/articl….

ChemPerturb-seq screen identifies a small molecule cocktail enhancing human beta cell survival after subcutaneous transplantation dlvr.it/TMMS6H

Chemical reprogramming of human blood cells to pluripotent stem cells dlvr.it/TMNLfv

Viewpoint: The rise in early-onset cancers in individuals under 50 may be explained by accelerated biological aging, with aging and cancer sharing common mechanisms. ja.ma/4myVLcs

Consider joining us at Stanford as a postdoctoral fellow! If you have a published paper or a preprint, will graduate in the next period, and are excited to work in California, email me your CV and a brief statement of your research interests and trajectory by the end of August.