Traveled back to Basel earlier this month to receive the University of Basel Department of Chemistry Doctorate award of 2022. It was great to catch up with the friends and colleagues Michael A. Nash!

Nucleotide binding halts diffusion of the eukaryotic replicative helicase during activation biorxiv.org/cgi/content/sh… #bioRxiv

New preprint from my PhD work. We used mechanical anisotropy-based protein engineering approach to make an artificial catch bond!

My first paper from the Nynke Dekker Lab ! We investigate the loading of eukaryotic replisomes in the presence of nucleosomes at the single-molecule level! nature.com/articles/s4146…

Our manuscript investigating the dynamics of Mcm2-7 loading on a chromatinized origin of replication is now out in Nature Communications. Congratulations to all the authors! nature.com/articles/s4146…

Iterative Machine Learning for Classification and Discovery of Single-Molecule Unfolding Trajectories from Force Spectroscopy Data | Nano Letters pubs.acs.org/doi/10.1021/ac…

Thrilled to share this review with Lisanne Spenkelink & @van_Oijen on the advancements in single-molecule approaches & cryo-EM🔬. These technologies are reshaping our understanding of DNA replication dynamics! #StructuralBiology #Biophysics #AcademicChatter pubs.acs.org/doi/full/10.10…

Ever wished you could make fully custom-sequence >10 kb DNA constructs with extrahelical features for #singlemolecule experiments? Check out our latest publication in Biophysical Journal to see how we did it (and to see some CMG helicase action, too!) 🧵👇(1/4). authors.elsevier.com/c/1iBGf1SPT43Pl

Our new publication on how to make fully custom-sequence 10 kb DNA constructs with extrahelical features for single-molecule experiments is now out in Biophysical Journal! Hope you enjoy! Congratulations, Daniel Ramírez Montero and Zhaowei Liu! sciencedirect.com/science/articl…

In new work, Dekker and coworkers developed a strategy to synthesize custom-sequence DNA constructs for a variety of force and fluorescence single-molecule spectroscopy experiments. Read more here: bit.ly/48ri1xU TU Delft

Now officially out! Check out our latest publication in Biophysical Journal! Hope you enjoy it!

Want to do a postdoc using single-molecule biophysics and biochemistry to understand the dynamics of eukaryotic DNA replication? Come join our multidisciplinary group University of Oxford! More info below. RT=🙏 my.corehr.com/pls/uoxrecruit… my.corehr.com/pls/uoxrecruit… nynkedekkerlab.tudelft.nl/?page_id=57

One of the last pieces of my PhD work Michael A. Nash is now published on Nature Communications. We used mechanical anisotropy to engineer an artificial catch bond! Nice collaboration with Tinnefeld Lab. Check it out: nature.com/articles/s4146…

Our new Oxford lab is starting up, boxes arriving!

🚨Our lab is looking for a Senior Technical Staff member with expertise in biochemistry and molecular biology. More info below. Interested? Come join our interdisciplinary team in beautiful Oxford! RT=🙏 my.corehr.com/pls/uoxrecruit…

We have 2 postdoc openings for an imaging biophysist and a data scientist at @kavlioxford. Intrigued by super-res microscopes🔬, single molecules, RNA, condensates, AI and bacteria 🦠? Read on! #ScienceJobs #Postdoc #bacteria #singlemolecule Pls RT.

Thank EMBO EMBO Fellows for organizing an amazing meeting ! Had a great time in Heidelberg: excellent science, inspring mentering sessions and training courses, and a warm and supportive EMBO community.

Fully funded PhD position in single-molecule studies of chromatin replication in the Nynke Dekker Lab (see attached and nynkedekkerlab.web.ox.ac.uk)!