METTL3 inhibition-activated cGAS/STING axis enhances immunotherapy and PARP inhibitor sensitivity of lung carcinoma: The cGAS/STING-mediated type I interferon response can augment antitumor activity, while the regulatory factors within this innate immune… dlvr.it/TCvpcp

The small MAF transcription factor MAFG co-opts MITF to promote melanoma progression: Transcription factor deregulation potently drives melanoma progression by dynamically and reversibly controlling gene expression programs. We previously identified the… dlvr.it/TCwBMl

PPM1D truncation-associated overexpression of the stress-related protein NQO1 confers sensitivity to the bioactivatable drug IB-DNQ in diffuse intrinsic pontine glioma: Diffuse intrinsic pontine glioma (DIPG) is a very aggressive brainstem tumor with… dlvr.it/TCwW3G

HOXB6 and HOXB8 control immune-cancer cell interactions in pancreatic cancer.: Pancreatic ductal adenocarcinoma (PDAC) is a lethal cancer lacking effective drugs and therefore new treatment targets are needed. Transcriptomic analysis comparing human… dlvr.it/TCwlXq

Image-Based Quantitative Single-Cell Method Showed Increase of Global Chromatin Accessibility in Tumor Compared to Normal Cells: The phenotypic plasticity of cancer cells has recently emerged as an important factor of treatment failure. The mechanisms of… dlvr.it/TCwwph

Inactivation of necroptosis-promoting protein MLKL creates a therapeutic vulnerability in colorectal cancer cells.: Mortality from colorectal cancer (CRC) is significant, and novel CRC therapies are needed. A pseudokinase MLKL typically executes… dlvr.it/TCx5d7

Enhancing efficacy of the MEK inhibitor trametinib with paclitaxel in KRAS-mutated colorectal cancer: Background: KRAS is frequently mutated in the tumors of patients with metastatic colorectal cancer (mCRC) and thus represents a valid target for… dlvr.it/TCxJf0

Reversible Downregulation of HLA Class I in Adenoid Cystic Carcinoma: Purpose Adenoid cystic carcinoma (ACC), a rare and lethal cancer, has shown low response rates to systemic therapies, such as cytotoxic chemotherapy and immune-checkpoint inhibitors… dlvr.it/TCxppm

Subtype-specific Patterns of Evolution and Clinically Relevant Genomic Instability in Wilms Tumour: Understanding cancer evolution is fundamental to predicting cancer progression. However, the evolution of paediatric cancers is still under-researched.… dlvr.it/TCy4TY

Claudin-4 remodeling of nucleus-cell cycle crosstalk maintains ovarian tumor genome stability and drives resistance to genomic instability-inducing agents.: During cancer development, the interplay between the nucleus and the cell cycle leads to a state… dlvr.it/TCyJQl

Interplay of ferroptotic and apoptotic cell death and its modulation by BH3-mimetics: Ferroptosis and apoptosis are widely considered to be independent cell death modalities. Ferroptotic cell death is a consequence of insufficient radical detoxification… dlvr.it/TCyV4T

A pontine-specific axonal niche supports de novo gliomagenesis: Diffuse intrinsic pontine gliomas (DIPGs), a major type of pediatric high-grade gliomas located in the pons, are the leading cause of death in children with brain cancer. A subset (20-25%)… dlvr.it/TCydh6

Exploring the effect of capsaicin on gene expression and chemotherapy sensitization in gastric cancer cells: Purpose: Capsaicin has previously been demonstrated to exhibit anti-tumor effect in various cancer type. However, the effect of capsaicin on gene… dlvr.it/TCyn2s

On the equivalence between Agent-Based and Continuum models for cell population modeling. Application to glioblastoma evolution in microfluidic devices: Mathematical models are invaluable tools for understanding the mechanisms and interactions that… dlvr.it/TCyyLn

Caveolin-1 and mechanical stress control the release of a pro-metastatic subpopulation of small extracellular vesicles: Extracellular vesicles are lipid-enclosed vesicles released by most cells and are present in all human bodily fluids. EVs carry… dlvr.it/TCz9RY

An antibiotic that mediates immune destruction of senescent cancer cells: Drugs that eliminate senescent cells, senolytics, can be powerful when combined with pro-senescence cancer therapies. Using a CRISPR/Cas9-based genetic screen, we identify here… dlvr.it/TCzPkB

Invasive cancer and spontaneous regression two weeks after papillomavirus infection: Development of invasive cancer in mammals is thought to require months or years after initial events such as mutation or viral infection. Rarely, invasive cancers… dlvr.it/TCzfhR

Differential gene expression in cells with different p53 mutations identifies genome-wide p53 targets and shows distinct modulation of cellular pathways in response to DNA damage: The fundamental transcription factor p53 regulates cellular processes and… dlvr.it/TCzth9

Comprehensive analysis of the RBP regulome reveals functional modules and drug candidates in liver cancer: RNA binding proteins (RBPs) are essential components of the transcriptomic regulome. Identifying the RBP regulome in cancer cells is crucial to… dlvr.it/TD046Z

Characterization of tumor heterogeneity through segmentation-free representation learning: The interaction between tumors and their microenvironment is complex and heterogeneous. Recent developments in high-dimensional multiplexed imaging have revealed… dlvr.it/TD0DXM