Today we share in Nature Communications our method called LIMe-Hi-C (Lamina-Inducible Methylation and Hi-C) & how we used it to uncover Polycomb-Lamina antagonism. Big thanks to Allison, Shelby, Martin Aryee, and Liau Lab, & to reviewer 1 for the detailed comments. nature.com/articles/s4146…

How do you get resistance mutations when a drug nearly carbon copies the substrate? 🤔 By distal, allosteric activation! See how we exploit this chemical subterfuge to systematically search for allostery in DNMT1 & UHRF1 in our latest pre-print. 1/N
biorxiv.org/content/10.110…

We have another new preprint out! 🎉

Congratulations to Dr. Brian Liau (Brian Liau) at Harvard University for being named a 2022 Camille Dreyfus Teacher-Scholar! Liau Lab Harvard UniversityCCB

We can map DNA-DNA contacts to chart 3D genomes with classic Hi-C, but where are these contacts positioned in the nucleus? Proud to release a new flavor of Hi-C, LIMe-Hi-C, a method that tags & maps DNA-DNA contacts relative to the nuclear periphery! (1/N) biorxiv.org/content/10.110…

DNMT3A is 1 of the most highly mutated genes in heme malignancies & clonal hematopoiesis with >250 mutations. Ever wonder what mutations in DNMT3A do to its function?🤔 (1/3)

Super excited to announce that we’ve just submitted the latest Liau Lab ~manuscript~! Tldr: we used base editors + a methylation reporter to do a mutational scan of DNMT3A, a key cancer gene. Highlights below, but check out our preprint at biorxiv!

biorxiv.org/content/10.110…

Excited to share our latest work revealing a repressive methylation ceiling in EZH2-mutant lymphoma! We made this discovery by finding drug addiction mutations, a strategy we expect to be broadly useful for uncovering new biology across drug targets. (1/7)
biorxiv.org/content/10.110…

Check out our new preprint! Thread here 👇

Check out this awesome perspective by grad student Stephanie Robinson (she/her) on exciting work by Kevin Ngan, Pallavi Gosavi, Brian Liau, Liau Lab to profile resistance-driving mutations in neosubstrates of molecular glues! Thanks ACS Central Science for the opportunity!
pubs.acs.org/doi/10.1021/ac…

#ASAP by Brian Liau & co-workers Harvard Chemistry 
Profiling the landscape of drug resistance mutations in neosubstrates to molecular glue degraders: go.acs.org/qa

Our paper employing CRISPR scanning to profile landscape of resistance mutations in neosubstrates to glue degraders is now online in ACS Central Science Congrats! Brian Liau, Kevin Ngan, megan, Cindy, Nicholas Lue, Jiaming, @sam_hoenig & Liau Lab pubs.acs.org/doi/abs/10.102…

aaaaaaand we're officially out in ACS central science

pubs.acs.org/doi/abs/10.102…

congrats again to Pallavi Gosavi, Brian Liau, and the rest of the Liau Lab team (@applecannon23, Cindy, Jiaming, Nicholas Lue, @sam_hoenig)

now please don't ask me to look for missing commas for a week

Honored and very grateful for the invaluable funding support from Damon Runyon Cancer Research Foundation.

(1/4) Molecular glue degraders are captivating drug discovery, but how might drug resistance emerge? Read our new preprint! We identify themes of degrader resistance involving neosubstrates. #TPD biorxiv.org/content/10.110…

Honored to have hosted Esben Svenningsen over the last few months. Hope you had a good time and see you again soon!