Cell signaling is context specific, as this accordion metaphor illustrates. Here is an example from mapping the oncogenic PI3K signaling code with single-cell resolution: youtu.be/WiJoZCJIR8Q?si…

The time is ripe to substantially advance our understanding of translation. We can profile the diverse pool of modified tRNAs and a wider spectrum of amino acid incorporation into proteins: biorxiv.org/content/10.110… The synergy of these developments will exciting ❗️ 1/2

Apply for your funded early-career researcher place at our Workshop on “Mechanometabolism Unleashed: The Interface of Cell Mechanics and Metabolism” where you can listen to our recent research on mechanometabolism. Apply by 13 Dec at biologists.com/workshops/june… #BiologistsWorkshops

Rapid parallel reconstruction and specificity screening of hundreds of T cell receptors nature.com/articles/s4159…

Trained immunity in the bone marrow: Hub of autoimmunity dlvr.it/TG4mqW

Patient-derived organoids in precision cancer medicine Chemical & CRISPR drug screening for individuals Likely also fits cardiovascular diseases?🤠 Med by Cell Press 2024 cell.com/med/fulltext/S… Personally, I really wish that this personalized medicine workflow could be

#easySHARE-Seq: Flexible and high-throughput simultaneous profiling of gene expression and chromatin accessibility in single cells | bioRxiv biorxiv.org/content/10.110…

DrugProtAI: A guide to the future research of investigational target proteins 1. DrugProtAI is a cutting-edge tool designed for predicting protein druggability, addressing the high failure rate in drug development. By evaluating 20,273 human proteins and extracting 183

Very interesting and useful work published in Nature Biotechnology Nature Biotechnology nature.com/articles/s4158…

A tuneable minimal cell membrane reveals that two lipid species suffice for life doi.org/10.1038/s41467…

Very nice paper in Science, showing that N-glycosylation can also function as a degradation signal, similar to Ubiq: science.org/doi/10.1126/sc…. Glad to see the authors used our #FragPipe/#MSFragger-Glyco “Glyco-N-LFQ” workflow for quantitative glycoproteomics data analysis.

📢Last two weeks of #immunometabolism discoveries Bims: Biomed News ⬇️⬇️⬇️ biomed.news/bims-imicid/20… biomed.news/bims-imicid/20…

In this fascinating preprint, the authors uncover an eye-opening feature of tRNA genes: they’re insanely prone to mutation. Analyzing somatic mutations in cancer tissues, they report that tRNA genes are up to 9 times more mutated than protein-coding genes. Interestingly, the

In a new #ScienceReview, researchers provide a critical evaluation of research linking glymphatic dysfunction with Alzheimer’s disease. scim.ag/44Hh18I

A gene variant known to increase the risk of Alzheimer’s disease also makes people vulnerable to a host of other age-related brain disorders go.nature.com/44G3uOo

New Article! Long-read RNA sequencing of transposable elements from single cells using CELLO-seq bit.ly/46fJGUO

Out now in nature: "Interpretable representation learning for 3D multi-piece intracellular structures using point clouds" nature.com/articles/s4159…

Scientists used AI to help develop a "digital brain." In our latest #LabNotespodcast episode, 🎧 hear how we used AI to stitch together 95M hi-res images in effort to develop the largest wiring diagram and functional map of a mammalian brain to date. alleninstitute.org/news/the-digit…

Mutant KRAS peptide targeted CAR-T cells engineered for cancer therapy dlvr.it/TLyMHF

Nature research paper: Multi-omic profiling reveals age-related immune dynamics in healthy adults go.nature.com/4nvIfq8