Comprehensive look back at molecular glues by Michelle Arkin.

cell.com/cell-chemical-…

Proximity labeling is a powerful proteomics approach to map cellular organization of proteins and their interactions, but the multistep sample preparation has restricted scalability. Our new preprint offers a solution: biorxiv.org/content/10.110…

I wish I heard this George Church (george church) podcast episode when I was a grad student!
1. You can change the world, as long as you don't care who gets credit.
2. The idea is not to never fail, it is to fail a million times a day.
3. Embrace the outlier!
nightscience.buzzsprout.com/1744020/149731…

Outstanding review and perspective on virtual screening

3 reviews Cell about the immune system:

👉 Innate immunity: cell.com/cell/fulltext/…

👉Adaptive immunity: cell.com/cell/fulltext/…

👉New perspectives: cell.com/cell/fulltext/…

Exploring the #genomic architecture of circulating #cytokines in the largest to-date dataset of 75,000 individuals, we find

👉169 loci associated with cytokine levels
👉 promising drug targets for immune-mediated diseases

Check out for more:
medrxiv.org/content/10.110…

“Discovery of ERD-3111 as a Potent and Orally Efficacious Estrogen Receptor PROTAC Degrader with Strong Antitumor Activity”

pubs.acs.org/doi/10.1021/ac…

Meet our Protein Degradation in Focus Symposium keynote speakers:

Craig Crews PhD is the John C. Malone Professor of Molecular, Cellular & Developmental Biology at Yale and will present the talk 'Tik-TAC-Toe: A Heterobifunctional for Every Need'

#TPDFocus

⁦Vividion Therapeutics⁩ Chemoproteomic discovery of a covalent allosteric inhibitor of WRN helicase | Nature nature.com/articles/s4158…

Fascinating talk by Craig Crews on faculty entrepreneurship, and the long and winding journey of drug development… 🙌🏽👏🏽
Yale Pathology
Yale Ventures
Yale Cancer Center
Arvinas
CT Innovations

Repurposing AS1411 for constructing ANM-PROTACs: Cell Chemical Biology cell.com/cell-chemical-…

Great to see Susan Tsai, MD, MHS paper on the cover of Gastroenterology
Transcriptomic-Based Microenvironment Classification Reveals Precision Medicine Strategies for #PancreaticCancer
Congratulations Sue!
gastrojournal.org/article/S0016-…

Now online! DrugMap: A quantitative pan-cancer analysis of cysteine ligandability dlvr.it/T5snQv

Meet Cigall Kadoch of @HarvardMed who knows everything about Structure and Function of Mammalian SWI/SNF Chromatin Remodeling Complexes in Human Disease. And guess what? You can hear all about it at our 60th Anniversary Symposium! #MPIMG60years Register now👇
molgen.mpg.de/60th-anniversa…

Interdisciplinary collaboration can create external analytical advocates, helping repair the field’s reputation problem, says Ben Garcia 💭👇🏼
bit.ly/3OSN3aA

During #DrugDiscoveryDay Ryan Cross the Science Boss had an in-depth discussion with Arena BioWorks co-founder Stuart Schreiber around small molecule drug discovery, AI in chemical biology, & new models of funding science. Watch this conversation & more On Demand: bit.ly/44503Ak

Check out this Brad Loncar BiotechTV interview with Chaitan Khosla, director of the Innovative Medicines Accelerator (IMA) Stanford Medicine, with a pipeline of drug dev programs available for partnering/licensing:

ima.stanford.edu

Can we conjugate ubiquitin in a non-canonical fashion? Join Breanna Zerfas and me for two compelling seminars at 11 am EDT, 8 am PT, 4 pm BST, 5 pm CEST: Jonathan Ostrem: “Direct Small Molecule Ubiquitination”
Darci Trader: “Bypassing an E3 Ligase for TPD'

Congratulations Craig Crews !