TIL: There's a theme for Matplotlib called Rosé Pine that looks beautiful: github.com/h4pZ/rose-pine…

fraguracy: github.com/brentp/fragura… calculates actual error rates in paired end sequencing using the fraction of pairs+bases that overlap. It stores sequence context (C->A, C->G, ...), base-qual, read-position, strand for each error and non-error

BioConvert: a comprehensive format converter for life sciences biorxiv.org/cgi/content/sh… #biorxiv_bioinfo

An Ensemble Penalized Regression Method for Multi-ancestry Polygenic Risk Prediction biorxiv.org/content/10.110…

Two slides explaining polygenic scores 🧬

The impact of FASTQ and alignment read order on structural variation calling from long-read sequencing data biorxiv.org/cgi/content/sh… #biorxiv_bioinfo

Successfully defended my thesis today with the support of my advisor Shaun Kane, my amazing committee, and loving friends and family. Onward!!

Happy #DNADay23! It truly is the perfect date.

Read my piece for Big Think about behavioural genetics: bigthink.com/health/tiny-ge… 🧬

Improving variant calling using population data and deep learning bmcbioinformatics.biomedcentral.com/articles/10.11…

We offer an individual-level interpretation of polygenic score (PGS) transferability across genetic ancestries: PGS accuracy varies individual-to-individual across the genetic-ancestry continuum, even in populations usually labeled as homogeneous. 1/ nature.com/articles/s4158…

New in AJHG: Impact of cross-ancestry genetic architecture on GWASs in admixed populations. ➡️ cell.com/ajhg/fulltext/…

networkGWAS: A network-based approach to discover genetic associations academic.oup.com/bioinformatics…

A most pleasant genetics class - perfect reading for a slow Friday evening. nature.com/articles/s4157…

d-SNE

When you finish a PhD I hear they give you one of these bad boys

Excited about Michael Bradshaw's 1st 1st-author paper biorxiv.org/content/10.110… Mixed STRING & HPO. Used time-series learning to id co-clustered genes/traits that may explain unsolved cases. Tested on MyGene2 & Children's Hospital Colorado patients. Slick GUI at ryanlayerlab.github.io/BOCC/)

Excited to share our new local ancestry inference (LAI) method, Recomb-Mix. With some simple tricks of graph collapsing, we drastically speed up the multi-population Li&Stephens and achieve accurate LAI. biorxiv.org/content/10.110…. Kudos to Yuan Wei and Shaojie Zhang

I am sad to be missing #GI2023, but please check out talks from Christopher and Kristen Schneider on Friday, posters #60 from Michael Bradshaw and #57 from Morteza Baradar on Thursday, and poster #178 from Xinchang Zhen and Fritz Sedlazeck on Friday.

We are honored to have worked with other journal editors to provide guidance on the use of population descriptors in #Genetics and #Genomics research bit.ly/3IxQKyH JAMA AJHG Genetics in Medicine Nature Genetics American Journal of Medical Genetics Parts A+C National Academies