Man I love this rivalry

Here is the original table from that 1949 Goldenberg & Apgar article describing the different effects between epinephrine and norpinephrine. It looks mostly similar to the ones we see today. 🧐

Impressively null figure

Good discussion in comments

👇ECG and PAC/EAT Localization (Part 2): Anterior Atrium vs. Posterior Atrium👇 •P wave positive in lead aVR: Indicates that the PAC/AT likely originates from the anterior region of the atrium. This includes areas such as the tricuspid valve annulus, coronary sinus , mitral

Catheter ablation in end-stage heart failure? A population not previously studied in this context, having been excluded from prior large trials. This trial showed the importance of sinus rhythm maintenance in this vulnerable population. CASTLE HTx Trial, NEJM 2023 ♥️

⚠️Don’t ignore elevated #NTproBNP levels in #HFpEF patients with #CKD Study by Brendon Neuen et al shows that ⬆️NT-proBNP consistently signals ⬆️risk of poor outcomes across all #eGFR stages📚 🔗: jacc.org/doi/full/10.10… scottdavidsolomon Muthu Vaduganathan Peder L. Myhre MD, PhD #JACCHF

Confession: I LOVE hyponatremia 🤓 (I know, I know. What can I say, I'm a true internist!) HypoNa is often feared, maligned, and misunderstood - but I promise it doesn't have to be scary! Here are my top 10 hyponatremia tips and tricks - a 🧵

Ironic that we got free AI from a hedge fund and $200/month AI from a nonprofit.

(2/x) To start, the term 'volume status' is problematic. What it means to most clinicians is 'should I give fluid OR should I diurese them. Better questions to ask are: 1. Is there left sided congestion? 2. Is there right sided congestion? 3. What is the stroke volume? 4.

Language Models Use Trigonometry to Do Addition "We first discover that numbers are represented in these LLMs as a generalized helix, which is strongly causally implicated for the tasks of addition and subtraction, and is also causally relevant for integer division,

Can humans reason? In this paper we show evidence many humans simply apply heuristics they've been exposed to over the course of their lives without deeper consideration. In conclusion, humans don't seem to reason and only copy reasoning patterns from their training data.

Your email address is like a password these days If it's publicly findable, it means you can easily be attacked with a phishing scam or 2FA hack Your email address especially for the highest security apps should be something like:

Where is this central line and what to do? #ICUrounds 1/14 (repost, as left CXR pic out😀)

🫀 Persistent Left Superior Vena Cava (PLSVC) & Pacemaker Implantation: A Challenge 🫀 PLSVC is a rare anatomical variant (0.3-0.5% of the population) that can complicate pacemaker implantation by altering standard venous access to the heart. 🏥⚡ [1-2]

We would like to thank all the authors who labored to conduct the research and create the content and handed over ownership to us so we could copyright the material & protect our business model, the reviewers who labored for free, the institutions who provided the facilities for

Statins "only" help 1 in 100 people avoid a heart attack… In 4 years. Stretch that to 40 years, and it’s 1 in 3.

Blog article on a formal way to borrow treatment effect information across different clinical trial outcomes has been expanded: fharrell.com/post/yborrow/ #Statistics

The 10 most striking Kaplan-Meier curves (that I have seen) 🧵 1. Dual GLP1/GIP agonist, Tirzepatide, for prevention of type 2 diabetes in people with obesity It's easy to miss the dark blue line (15 mg group), because it never leaves the X axis:

🫀 Can cardiac CT safely replace invasive coronary angiography in new-onset heart failure? 📍 Yes — and much more. 🚨 NEW STUDY PUBLISHED in EHJ-CVI! 🚨 This is a topic near and dear to my heart and my daily clinical practice for a long long time. In terms of practicality,