A review on angiotensinogen siRNA in both preclinical models and hypertensive pa􀆟ents, including a comparison versus 'classical' RAS blockers. Edwyn Cruz ahajrnls.org/3tG9ZC1

Today at the CTAD, we presented additional interim Phase 1 clinical data on ALN-APP, an investigational #RNAi therapeutic in development for the treatment of #AlzheimersDisease and cerebral amyloid angiopathy. #RNAitherapeutics #siRNA #CTAD23

We are proud to share that NEJM has published results from the APOLLO-B Phase 3 study of investigational patisiran in patients with the cardiomyopathy of #ATTR #amyloidosis. #RNAiTherapeutics #siRNA

Remembering biochemist Har Gobind Khorana who helped us to crack the genetic code. Khorana shared the 1968 #NobelPrize in Physiology or Medicine with Robert Holley and Marshall Nirenberg "for their interpretation of the genetic code and its function in protein synthesis."

Deeply #AlnylamProud to share that our CEO Yvonne Greenstreet has been named 2024 Woman of the Year by Healthcare Businesswomen’s Association (HBA)! This award honors a leader who has made extraordinary contributions to healthcare and the advancement of women in the workplace. #HBAWOTY24

Excited to share our work on 5’-cap RNA/SAM mimetic conjugates as bisubstrate inhibitors of viral RNA cap 2’-O-methyltransferases in Bioorg Chem authors.elsevier.com/a/1iOzV_11oDgQ… Congrats to Rostom Ahmed-Belkacem P. Sutto-Ortiz Adrien Delpal Vasseur Jean-Jacques Decroly Etienne ChemBioNAC IBMM - Institut des Biomolécules Max Mousseron

The story keeps going on bisubstrate inhibitors of SARS-CoV-2 N7-MTase in ChemBioNAC team at IBMM - Institut des Biomolécules Max Mousseron with our recent paper in RSC Medicinal Chemistry. Congrats Rostom Ahmed-Belkacem J. Troussier Adrien Delpal supervised by Vasseur Jean-Jacques Decroly Etienne Debart Françoise doi.org/10.1039/D3MD00…

Research update: Chemical synthesis of DNA microarrays on conductive surfaces, now happening at Lietard Research Group! pubs.acs.org/doi/full/10.10…

RNA interference in the era of nucleic acid therapeutics go.nature.com/49tcrf8

What a week ! Very happy to see our ChemBioNAC NuEP Team collaborative ChemMedChem review online Thanks to 1st author A. Guillou, Vasseur Jean-Jacques S. Peyrottes and C. Mathé …mistry-europe.onlinelibrary.wiley.com/doi/10.1002/cm… #hydrazine #nucleosides #nucleotides CNRS Chimie #GAVOconsortium IBMM - Institut des Biomolécules Max Mousseron

My quest to cure prion disease — before it's too late (Sonia Vallabh | TED2024) go.ted.com/FEXNi via TED Talks

Counteracting Angiotensinogen Small-Interfering RNA-Mediated Antihypertensive Effects With REVERSIR | Hypertension ahajournals.org/doi/10.1161/HY… A collaboration from our labs and Prof Jan Danser's group Erasmus MC Intl

$SRPT Once again, Peter Marks overrules his staff, who wanted to reject Elevidys. I guess we knew this was going to happen back in January, when Marks, on stage at our JPM event, told us that failed randomized clinical trials don’t matter in gene therapy. Still, amazing

A great way of administration of GalNac-conjugated siRNAs would be oral delivery. Mikyung Alnylam Pharmaceuticals guided us through all the challenges to get there. The size of the siRNAs seems to play a big role in the efficiency. #OTS24

Single-Stranded Hairpin Loop RNAs (loopmeRNAs) Potently Induce Gene Silencing through the RNA Interference Pathway | Journal of the American Chemical Society Alnylam Pharmaceuticals #SingleStranded #Hairpin #Loop #RNA #GeneSilencing #RNA #Interference pubs.acs.org/doi/10.1021/ja…

High resistance barrier and prophylactic protection in preclinical models of SARS-CoV-2 with two siRNA combination academic.oup.com/nar/article/do…

Improving the Potency Prediction for Chemically Modified siRNAs through Insights from Molecular Modeling Focused on Individual Sequence Positions dlvr.it/TGj01j #MTNA

The past, present & future of RNAi therapies. Listen to Alnylam Pharmaceuticals CSO Kevin Fitzgerald on The Long Run. timmermanreport.com/2024/12/the-pa…

We’re proud to celebrate Mano Manoharan’s induction into the 2025 MEDI Hall of Fame! This honor reflects his groundbreaking work in oligonucleotide therapeutics and lasting impact on medicinal chemistry. #MedicinalChemistry #ACS #MEDIHallOfFame #ScientificExcellence