Thrilled to share our latest review with Judith Agudo on the unique immune resistance mechanisms of #CancerStemCells in solid tumors! Explore how these insights are reshaping cancer therapy approaches. #Immunology #CancerResearch #CancerImmunotherapy"

I haven’t posted much since Twitter is X, but I have a good reason today☺️ if you like #cancerstemcells #stemcells and #immunotherapy, this is for you! With partner in crime Phoenix Miao😎 nature.com/articles/s4156…

Amazing work by my student Michael Poli on the cover of Science! Fantastic collaboration

The immune response Credit: BigPicture & WellcomeTrust #MedEd #MedX #Immunity #Science #biology

Biggest medical discoveries of the week (🧵) #1 - Evo: generative AI for biology From scratch, Evo could: Design a functioning CRISPR-Cas enzyme (top right figure) Predict gene essentiality at genome-wide scale (bottom left figure) Generate genome-length DNA sequences,

Excited to announce our new #proteindesign strategy for allosterically controlling the kinetics of protein-protein interactions! Read on for cool applications in cytokine signaling, biosensing, and protein circuits. biorxiv.org/content/10.110…

Molecular insights into the activation mechanism of GPR156 in maintaining auditory function | Nat Commun doi.org/10.1038/s41467…

Inflammed #hiPSC Blood Vessel #Organoid as a drug screening platform for #Atherosclerosis Spinning shear stress, eLDL/TNFα/IL1β, monocytic THP1 cell co-culture-> ⏫ICAM1/TNFα/VCAM1/iNOS ⏬pS1177 eNOS (likely in both #EndothelialCell & mural cell, except E-selectin in EC only)

Are metastatic #cancers more like their normal origin or target tissues? Our work in Science Advances systematically compares the #transcriptomics of primary and metastatic #tumors to healthy tissues in a #PanCancer, genome-wide manner! #metastasis 🧵1/10 shorturl.at/Uc4xx

KPNA3 regulates #histone locus body formation by modulating condensation and nuclear import of NPAT, say Shui Bo Xu, Xiu Kui Gao, Zhang Bao, Yi Ting Zhou, Li Ling Zheng and colleagues Zhejiang University: hubs.la/Q02Z-y7P0 #Biochemistry #Organelles

Ovarian tumor cells gain competitive advantage by actively reducing the cellular fitness of microenvironment cells go.nature.com/4f7daor

Post-exam celebrations! 🎉 Finals are done, and I’m set to earn my MS in Quantitative Biology and Bioinformatics from CMU. Grateful for the growth, memories, and support throughout this journey. 🚀 #CMU #Graduation #BiologyMajor

Immune system

Liver-to-Aorta communication😎 #Atheroasclerosis #MAFLD #MedialArterialCalcification Steatotic Liver-derived #ExtracellularVesicle ⏫atherosclerotic lesion burden & calcification ⏫ MAFLD-associated arterial calcification ⏫RUNX2-mediated Osteogenesis of #SmoothMuscleCell ⏬by

2025 Will Be The Year of AI Agents Organizations will have 50 - 500 agents that automate various tasks. These AI agents will - Talk and perform actions on Enterprise systems - Automate workflows - Have an understanding of Enterprise data - Autonomously perform tasks on

Deep learning methods aid in de novo design of proteins to neutralize lethal snake venom toxins in vitro and protect mice from a lethal neurotoxin challenge. nature.com/articles/s4158… #NBThighlight

Super excited to share our recent work now out in nature! We introduce trans-synaptic tracing tools from circuit neuroscience to study the whole-brain connectome of glioblastoma. nature.com/articles/s4158…

Cells collected from the cervix during routine screening for cervical cancer can reveal the accumulation of certain mutations that are associated with precancer and cancer, an NCI-led study suggests. #CervicalCancer go.nih.gov/aRZICDx #CancerScreening

🇺🇸🇺🇸 Happy 4th of July 🇺🇸🇺🇸

In the latest issue! Senescence-resistant human mesenchymal progenitor cells counter aging in primates dlvr.it/TMv4Qs