Delighted to share the latest work from Luz María López and others @GDSC_Sussex in NealeLab /labneale.bsky.social. Meiotic prophase length modulates Tel1-dependent DNA double-strand break interference biorxiv.org/content/10.110…

New preprint is out! 👇

Calling all MRN aficionados: New work re convergent evolution of MRN inhibition by TRF2. From Alessandro Bianchi, Freddy Khayat @antonywoliver @GDSC_Sussex

After a year since I come to JFCR, we are now 5! Mami, Takahiro and Lewis joined this spring!

A new preprint from a fantastic collaboration with Keith Caldecott and Arnab Ray Chaudhuri driven by awesome postdocs Alice Meroni, Sophie Wells and Carmen Fonseca!!! (1/3) biorxiv.org/content/10.110…

Did you know that reverse transcriptases are capable of de novo DNA primer synthesis? It has been an surprising and incredibly exciting journey. Many thanks to all members of the Doherty lab for their fantastic work. academic.oup.com/nar/advance-ar…

Fantastic to see this study out Stephen Gray and Rachal Allison/Burns! 😀🎉🎇🎆

New review, written by Lewis (postdoc in our lab) and me! We overview the contribution of error-prone polymerases (such as Pol-eta, Pol- kappa) to adaptation of cancer cells. onlinelibrary.wiley.com/doi/full/10.11…

Announcing AlphaFold 3: our state-of-the-art AI model for predicting the structure and interactions of all life’s molecules. 🧬 Here’s how we built it with Isomorphic Labs and what it means for biology. 🧵 dpmd.ai/3URDiNo

Very excited to share our latest work on KU-binding motifs and replication stress!

Very excited for my first day as a Lecturer in Genome Stability/PI @GDSC_Sussex to start a new lab focussing on DNA damage checkpoint control using structural biology. A career dream come true!

Constitutional court just took the country from "uncharted waters" into "constitutional crisis" and is gonna turbo-charge the already high public anger if Ciolacu gets back into the 2nd round. Insane...