I've always been obsessed with how genes and enhancers talk to each other. Our latest review explores just that. Enhancers: A Focus on Synthetic Biology and Correlated Gene Expression | ACS Synthetic Biology pubs.acs.org/doi/full/10.10…:

Great to see that the Krebs lab continues to provide quantitative and important insights into rate-limiting steps in transcription!! Congrats to all.

Did you ever wonder how transcription initiation compares between flies and mammals? The project that started as my master thesis in @arnaud_kr lab, was continued by @KCTattwo is now out on BioRXiv: biorxiv.org/content/10.110…. Read his summary below:

Doing good science is 90% finding a science buddy to constantly talk to about the project.

More than 100 EMBO Fellows are meeting in Heidelberg. The postdoctoral fellows present their research, attend a mentoring session, receive training on a variety of topics and more. #EMBOat60

Very happy and excited to announce that I'll be starting my own research group at EMBL-EBI! The group will focus on lineage tracing, somatic evolution and the origins of cancer. Interested in doing a postdoc in the group or know someone who is? Please reach out!

Finally I met Ming "Tommy" Tang or “crazyhottommy” in person, a real pleasure! When I first start doing genomics/bioinformatics, I learnt a lot from your blog posts, tutorials, and github. Thanks a lot!

Incredibly excited that our paper linking single molecule states of TF binding to gene expression using quantitative thermodynamic models is out in Nature today. An amazing collaboration with the Bintu Lab. Congrats to Ben, Michaela, and Julia! nature.com/articles/s4158…

WHY DOES THE EPIGENETIC CLOCK TICK? While money has been poured into developing therapies to reverse the epigenetic clock (Altos Labs 🤑), why the epigenome changes with age at all is unclear. In Nature Aging today, we suggest a potential driver: somatic mutations.

I’m delighted to share our work on scrambling the human genome using prime editing, repetitive elements, and recombinases Science Magazine! Raphael Ferreira @LeopoldParts Tom Ellis, george church @SangerInstitute science.org/doi/10.1126/sc… Lots of changes from the preprint. A🧵

Terrifying 😭

Having a stressful day? Lay back, crack a beer open and read about how chromatin accessibility responds to TF binding perturbations at the single molecule level bit.ly/3XQMFxN. I'm so grateful to my PhD mentors Arnaud Krebs and Judith Zaugg for these super productive years!!

The cells in our bodies constantly acquire mutations. But what are the patterns of mutations across tissues? How do mutations in normal cells lead to disease? These and other questions we will tackle within the SMaHT Network, now described in nature nature.com/articles/s4158…

Delighted to share a new review paper from the lab. We discussed recent key findings in enhancer biology. Thanks Dan Larson and Tineke Lenstra for this opportunity!! sciencedirect.com/science/articl…

🚨New preprint from our labs (STOP lab & Nojima lab Taka Nojima)! Magda Kopczynska @mgkopczynska.bsky.social and Chihiro Nakayama have been digging into how chromatin remodeller SETD2 controls the start and end of transcription 👇 (1/5) biorxiv.org/cgi/content/sh…

How many plasmids can bacteria carry? A synthetic biology perspective doi.org/10.1098/rsob.2…