Excellent talk this morning by Violetta Karwacki-Neisius from Shi lab. Meticulous experimentation resulting in striking phenotypes! #cshlepich18

Once upon a time, I started in Yang Shi’s lab in Boston with a plan in mind… and I got patient cells and reprogrammed them and made isogenic controls… and then I headed back to the UK leaving my babies in the more-than-capable hands of Violetta… and look how they’ve grown 🤩

nature.com/articles/s4158… Proud to have been part of this beautiful study.

I will soon give a talk at the Gordon conference on Wnt signaling in Maine, USA.

14/n I also want to thank all the other authors who contributed to the work: Daniel Nguyen, Violetta Karwacki-Neisius, Andrew G. Li, Roger Zou, @FranklinJ_ and Masato Kanemaki. Huge thanks to Yang Liu who made vfCRISPR and to Sergei Rudnizky and Reza Kalhor for discussions!

"Don't be afraid!" Randy Schekman says that the most successful scientists are willing to take risks. He uses 2024 chemistry laureate David Baker as an example of how embracing risk can lead to significant rewards. Before Baker transitioned to researching structural biology he

Electrostatics is the key!

Our latest paper has been published today, introducing a novel technology called "condense-seq", which enables the investigation of the genome from a biophysical perspective.

Thanks to ScienMag and Bioengineer.org!

Another nice article highlighting our latest paper and the significance of 'condense-seq':) The secret to how nucleosomes shape the genome | Journal Club | PNAS

What a pleasure to have been a speaker at this wonderful GRC conference on Wnt signaling in Maine! Great presentations and a wonderful community!