We are very happy to share our collaborative perspective paper on single molecule protein sequencing out today in Nature Methods. A great team effort! nature.com/articles/s4159…

🔥off the press now Nature Cardiovascular Research, Rad regulation of calcium channels in beta adrenergic modulation rdcu.be/cZCvW. Honored to collaborate w/Dr Steven Marx, leading the path to new therapeutics for cardiac contractility! Columbia Cardiovascular Institute ColumbiaCardiology Columbia Medicine #CardioTwitter

Research|Arianne Papa et al Steven Marx show that phosphorylation of 4 residues in Rad, a #calcium channel inhibitor, is required to mediate the βadrenergic #cardiac #FightOrFlightResponse. Columbia Medicine #ColumbiaCardiology #NYP nature.com/articles/s4416…

More cool work from our neighbours, BlacklowLab! "A Spatiotemporal Notch Interaction Map from Membrane to Nucleus." Congrats Alex, Lena Tveriakhina, @EmilyEg03602444, Julia Rogers, and everyone not on twitter! biorxiv.org/content/10.110…

A Spatiotemporal Map of Co-Receptor Signaling Networks Underlying B Cell Activation | bioRxiv. Great collaboration with the Kruse and Blacklow groups at HMS. Excited to see local phosphorylation dynamics with our proximity phospho proteomics workflow. biorxiv.org/content/10.110…

Excited to share the latest work from my time in the Garcia Lab: Receptor Elimination by E3 Ubiquitin Ligase Recruitment (REULR), a Nanobody based, modular mix & match Targeted Protein Degradation (TPD) toolbox to target cell surface receptors. ACS Synthetic Bio pubs.acs.org/doi/10.1021/ac…

Great collaboration of the BlacklowLab and Marian Kalocsay lab. Watch the changing molecular environment of Notch by quantitative proximity proteomics during its travel to the nucleus just published in Science Signaling science.org/doi/10.1126/sc…

Out now Journal of Proteome Research, Chris McGann's work on real-time spectral library searching. Thanks to everyone who helped to push this over the finish line and excited to see RTLS for multiplexed proteomics coming soon to an instrument near you! pubs.acs.org/doi/10.1021/ac…

We quantified 1.498 million thermal stability measurements in cells and crude extracts treated with small molecule therapeutics and tool compounds! We interrogated on- and off-target effects to dissect direct ligand binding and indirect effects.biorxiv.org/content/10.110…