Protein-protein correlations across single cells change dynamically even when the associated protein levels do not. Protein correlation dynamics across single cells offer a rich perspective, richer than I described before: journals.plos.org/plosbiology/ar…

🧵 The historic NYT v. OpenAI lawsuit filed this morning, as broken down by me, an IP and AI lawyer, general counsel, and longtime tech person and enthusiast. Tl;dr - It's the best case yet alleging that generative AI is copyright infringement. Thread. 👇

Commensal bacteria in the gut #microbiome display surprising resilience to #antibiotics, evolve resistance mutations, and reestablish a healthy biome after treatment, shows a 20-month long study of patients with #tuberculosis. Vanni Bucci, Ph.D. 🇮🇹🇺🇲🇺🇦 @MichaelGlickma1 scim.ag/5A0

New paper from Regeneron about #allergy #biomarkers in Allergy EAACI! Differential modulation of allergic rhinitis nasal transcriptome by #dupilumab and allergy immunotherapy. #immunology #sciencetomedicine doi.org/10.1111/all.16…

This also makes a great case for preprinting -- a high-impact paper will get a lot of eyes on it before it gets published in a fancy weekly magazine.

It's a shame that this is drawing attention away from the incredible accomplishments of the AllofUsResearch program in building a massive, diverse cohort that will fuel decades of important research.

Your weekend read editorial: Discussing the importance of shifting the focus towards clinically relevant outcomes, when adopting #ArtificialIntelligence tools, the ecosystem required for AI to succeed in health, & the human aspect of #healthcare. nature.com/articles/s4174…

How many genes are in the human genome? (The third in an irregular series of threads about #Bioinformatics.) Let’s start by restricting “gene” to mean “protein-coding gene.” For the moment, this number appears to be just under 20,000, far lower than it used to be 1/11

Open Access: Differential modulation of allergic rhinitis nasal transcriptome by dupilumab and allergy immunotherapy. First and corresponding author: Matthew F. Wipperman; corresponding authors: Jennifer Hamilton and Meagan P. O'Brien Read the article here:

New Article in eLife - the journal - Digital wearable insole-based identification of knee arthropathies and gait signatures using machine learning Matthew Wipperman Regeneron Moticon ISPGR ESMAC2019 #digitalbiomarkers #digitalhealth #gait #walking #mobility elifesciences.org/articles/86132

This perspective discusses how a convergence of progress by patients, advocates, developers, regulators & other stakeholders is driving real progress towards enabling more digital evidence tools to be used for decision making in #drugdevelopment. nature.com/articles/s4174…

Walk this way elifesciences.org/digests/86132/…

Predicting Parkinson's disease up to 7 years before symptom onset with a panel of 8 protein biomarkers Nature Communications nature.com/articles/s4146… (adds/orthogonal to the retina image that can do this well)

Wearables let us study how #sleep differs between or within people. With 5 million nights of data, Varun et al. found that changes in sleep over time are associated with acute & chronic conditions inc. COVID-19, fever, flu, #diabetes & sleep apnea. nature.com/articles/s4174…

This study from Scripps Research Translational Institute examined wearable data like step count, resting heart rate, & sleep to track changes in people with + without #LongCovid over a year. Those with Long #Covid_19 had significantly different resting heart rate & activity levels. They were also more

My 2022 "Uniquely Stupid" article is back on The Atlantic's most popular list. It's about how morally homogeneous institutions became "structurally stupid" after social media made it easy for the extremes to attack and silence moderates and dissenters: theatlantic.com/magazine/archi…

How gut microbiome research needs to move forward. Going multi-omics, getting to causality, rigorous clinical studies cell.com/cell/fulltext/…

NEW WHOOP RESEARCH ON EXERCISE & SLEEP I am proud to share that WHOOP research has just been published in nature. Our study analyzed 4.3 million nights of sleep across ~15k WHOOP members to answer a simple but important question: does working out at night hurt your sleep?

Nature research paper: Diet outperforms microbial transplant to drive microbiome recovery in mice. go.nature.com/3YXbf0i

Below is a non-serious statement, and an example as to why the Aging field is at risk of being pulled into a vat of snake oil.