#ArticlesInPress: S100A1's single #cysteine is an indispensable redox-switch for the protection against #diastolic calcium wavesin cardiomyocytes Andreas Seitz et al. ow.ly/5hEf50Snbhr #calcium #S100A1 #RyR2

BREAKING NEWS The 2024 #NobelPrize in Physiology or Medicine has been awarded to Victor Ambros and Gary Ruvkun for the discovery of microRNA and its role in post-transcriptional gene regulation.

BREAKING NEWS The Royal Swedish Academy of Sciences has decided to award the 2024 #NobelPrize in Chemistry with one half to David Baker “for computational protein design” and the other half jointly to Demis Hassabis and John M. Jumper “for protein structure prediction.”

Welcome to reality: actual diversity amongst german cardiovascular CRC speakers #CRCconvent2024

In academia, we often hear about the importance of networking, but the focus is usually on professional connections. Here, I present a different angle of networking, one that is often overlooked but equally important (if not even more important): your network of support. The

We've linked LV myocardium to specific arrhythmic & non-arrhythmic causes of sudden death to find substrates for lethal arrhythmias. Bringing us closer to answering the longstanding question, "Why that day?" In Press @JACCCEP, oral poster 11/18 #AHA24 JACC Journals POST SCD Study

We recruit Junior Group Leaders at the new Helmholtz-Institute for Translational AngioCardioscience (HI-TAC): 5+4 years. Work in the Heidelberg-Mannheim area in collaboration with the MDC Berlin! Apply now or latest Jan 6! application.mdc-berlin.de/site/index.php…

Happy to share our work on the development of S100A1ct, a peptide based therapy for the treatment of HF. Great collaborative effort! @DZHK_germany Universitätsklinikum Heidelberg ahajournals.org/doi/10.1161/CI…

Is basic science undervalued? David Glanzman talks about the decline of 'middle class' labs and that "there is no empirical evidence that the translational approach accomplishes [cures] any better than the traditional one. Claims to the contrary at this point are mere propaganda”

S100A1ct, a synthetic peptide targeting SERCA2a and RyR2, enhances cardiac performance and reduces arrhythmias in preclinical heart failure models. @volkersmirko Wally Koch @Rebecca_Wade_c Lukas Jarosch ahajournals.org/doi/abs/10.116…

Differences in how male and female cardiomyocytes generate energy may contribute to observed differences in heart disease. New findings from the Page lab: wi.mit.edu/news/taking-pu…

Female cardiomyocytes show higher expression of fatty acid oxidation genes, leading to greater reliance on fat for energy. A key insight into cardiac sex differences! @yoshiko96821 Maya Talukdar ahajournals.org/doi/full/10.11…

#ICYMI: S100A1ct peptide therapeutic against heart failure Julia Ritterhoff @DZHK_germany Universitätsklinikum Heidelberg @volkersmirko Wally Koch @Rebecca_Wade_c Lukas Jarosch

Breaking News: A baby with a rare disorder made medical history by receiving the first custom gene-editing treatment. The technique used has the potential to help people with thousands of other uncommon genetic diseases. nyti.ms/4j3xGs8

Circulation Research Interorgan Crosstalk in #HF & #Cardiometabolic Diseases Compendium CV, #Kidney, #Liver, & Metabolic Interactions in #HF: Breaking Down Silos ahajrnls.org/3ZtHfJQ by Roger Foo Joseph hill Faiez ZANNAD Shahzeb Khan Jennifer Ho Leah Kosyakovsky et al

Linker oder rechter Arm? Eine neue Studie zeigt, warum die Impfstelle wichtig ist Bei Impfstoffen kann es einen Unterschied hinsichtlich ihrer Wirksamkeit machen, wo sie in Ihren Körper gelangen. Wissenschaftler in Sydney haben herausgefunden, dass eine Auffrischungsimpfung im…

Out today from ThePerryLab, our work suggesting how exposure to high fructose in pregnant mice or developing neonates directly affects neurodevelopment. In nature nature.com/articles/s4158… Memorial Sloan Kettering Cancer Center Weill Cornell Medicine funded by NIH NIH Common Fund cc: Jay Bhattacharya, MD, PhD

Excited to share our latest work on cardiac gene therapy, where we show that AAV5 is effective in delivering S100A1 to the post-ischemic heart, achieving lasting improvement in cardiac performance. Congrats to Doro and the whole team! DZHK Germany ahajournals.org/doi/10.1161/CI…