Molecular ‘super-glue’ shows promise of cancer drug discovery platform stjude.org/media-resource…

New potent and selective molecular glues degrade CK1a and cause cell death in varied cancer cell lines, including AML. The Klco Lab Alex's Lemonade Stand Foundation Nature Communications nature.com/articles/s4146…

UBTF tandem duplications and KMT2A/menin complex co-occupy genomic targets dysregulated in UBTF-TD acute myeloid leukemias. ow.ly/RO7w50QCbXQ #myeloidneoplasia

Menin dependence: UBTF-ITD AML joins the club ow.ly/8qCS50QCe9R #myeloidneplasia

やれやれ、大谷翔平に気を取られて、自分のco-firstの論文が世に出た事をつぶやくのを忘れるなんてね。 UBTF-AMLのゲノム変異とclonal evolutionに加え、UBTFのexon9変異がexon13と同様に白血病を引き起こすことを示しています。読んでね。 Early View | Haematologica haematologica.org/article/view/h…

We have another report on UBTF myeloid malignancies out in Haematologica! haematologica.org/haematologica/… We highlight UBTFexon9 mutations and the clonal evolution of UBTF-AML. We also report a few cases MDS with UBTF alterations. Excited to share this co-authored manuscript. The Klco Lab

Applying to STEM grad programs? Know someone who is? 🎓 Sign ups are ✨OPEN✨ for #GSMI2024!🤩 The GSMI program supports applicants from minoritized backgrounds through 1-on-1 mentorship, fee waivers, & more! Applications due 6/1 cientificolatino.com/gsmi MORE INFO in 🧵 1/

After a fantastic dinner we are getting started at the 2024 Jane Coffin Childs Memorial Fund Annual Symposium!

Think big picture! Powering through some cloning today.

Had a great time at the The Klco Lab social! Work hard, play hard! 😤 WISEACRE

Boom. AlphaFold3 is here. Get folding, people! golgi.sandbox.google.com/about

Nuggets losing 2, then winning 2. Crazy odds…. Anyway, here are some tacos we made for dinner! Go Nuggets!

It’s hot outside but the dogs don’t care. #sunbathing

Congrats, Lauren!

Congrats, Jeff! Amazing mentor.

Great work. The rapid emergence of these resistant clones continues to solidify the need for improved treatment strategies.

This Memphis heat 🥵🥵

Congrats to all the new fellows!!!

Grant submitted…. Time to rest 💤

Our POE summer student, Elizabeth, gave an outstanding presentation on our ongoing research into UBTF tandem duplications. It's been another fantastic summer in the lab, and we are grateful for your incredible effort. Wishing you all the best! 👏👏👏 St. Jude St. Jude Research