Inspiring progress for patients with brain tumors from ACGT Scientific Advisor and Fellow, Dr. Crystal Mackall at #SITC21 this morning! Amazing to see patients who had no options benefit from CAR-T therapies 👏

Check out this amazing story from the @MackallLab from a dear friend and great scientist ここな.🧸 about GPC2 CAR T cells for neuroblastoma. Let's hope they work in the clinic! sciencedirect.com/science/articl…

📢 New in Nature Medicine! Great work led by Majzner_Lab Johanna Theruvath shows that the combo of anti-GD2 + CD47 blockade ⬆️ anti-tumor activity in 🐭 models of #neuroblastoma, #osteosarcoma & #lungcancer by modulating #macrophage activity #immunotherapy nature.com/articles/s4159…

Happy to share our lab's first manuscript. In work led by Johanna Theruvath, we tested a combo of FDA approved anti-GD2 with blockade of CD47, a macrophage checkpoint. Blocking CD47 unleashes patients' macrophages to phagocytose or 'eat' cancer cells. Combo was highly effective! 1/

Johanna Theruvath Thanks to support from @NCICTEP_ClinRes & CRADA w/Gilead Sciences (formerly CD47 Inc.), we are proud to test this approach in kids across US/Canada. Peds-CITN-03 is the 1st trial to test anti-CD47 in children and 1st trial of anti-GD2/anti-CD47 in humans clinicaltrials.gov/ct2/show/NCT04…

Thrilled to share our work on the combination of anti-CD47 and anti-GD2 for GD2+ malignancies. Many great collaborations involved. Especially exciting to see this combo being investigated in a clinical trial for kids with neuroblastoma and osteosarcoma run by Majzner_Lab

nature.com/articles/s4159…

A combination of anti-cancer antibodies produced a powerfully synergistic response in two hard-to-treat pediatric cancers, according to a new Stanford Medicine study, in mice. stan.md/3qm0dkt #Cancer #Research

My lab at Stanford is hiring. We work on engineering new cancer immunotherapies and understanding their activity in early phase trials. Open postdoc positions as well as a technician with animal experience. Contact me if interested! Please retweet!

Sorry - if interested, send me an email. Email address on my Stanford profile.

This is the first chapter of a story about courageous patients and their families, of multidisciplinary teamwork, and hard-fought steps forward to effective therapy for #DIPG #DMG, a universally lethal cancer of the brain and spinal cord.🧵(1/) nature.com/articles/s4158…

Our experience w/GD2 CAR T cells in 4 patients with DIPG/DMG was published today. This work taught us much about how to safely & effectively treat this disease w/CARs. Deeply grateful to patients & families who bravely trusted us as we learned together.nature.com/articles/s4158… 1/

A glimmer of hope for pediatric patients with #DIPG or other H3K27M-mutated DMGs Majzner_Lab Stanford Pediatrics Parker Institute for Cancer Immunotherapy Crystal Mackall Stanford Cancer Institute Michelle Monje🎗️ 🟦. Read our summary and interview with the team here => ow.ly/nH8C50I2plt

Immunotherapy and Targeted Therapies: Christine A. Pratilas, Sabine Heitzeneder, and Anusha Kalbasi will present this plenary session at the AACR special conference on Sarcomas, May 9-12, Montreal, QC, Canada. bit.ly/3vCFIms Anusha Kalbasi ここな.🧸 #AACRsarcoma22

Check out this Stanford Medicine news article highlighting our recent work on a drug-regulated CAR platform optimized for the clinic. Stanford Medicine @StanfordBioE Stanford Engineering Parker Institute for Cancer Immunotherapy Stanford Cancer Institute @MackallLab CochranLab Majzner_Lab

Crystal Mackall, MD, is the first in our series of CAR-Trailblazer profiles spotlighting women pioneers in the field of cancer #celltherapy Read the full interview: bit.ly/3NzeVNy #CARTcell Crystal Mackall Majzner_Lab Stanford Medicine National Cancer Institute Stanford Center for Cancer Cell Therapy

Prof. Carolyn Bertozzi won the Nobel Prize for establishing the field of bioorthogonal chemistry. What is that? Glad you asked …

Congratulations to Johanna Theruvath from @MackallLab for receiving the Maresch-Klingelhöffer-Research award 2022 in Goethe-Universität

Very honored to be the recipient of the Maresch-Klingelhöffer-Research Award 2022. Thank you to the Frankfurter Stiftung für Krebskranke Kinder and the kind words from Jan-Henning Klusmann Goethe-Universität! Thanks to my mentor Crystal for all her support @MackallLab

Check out this beautiful work from Majzner_Lab on LINK, a rapid and reversible AND-gated CAR platform. Congrats Robbie, Aidan, Mari and team! It was a pleasure to be part of this study and watch it develop over the years. nature.com/articles/s4158…