Our new paper, published today open access in PNASNews, uses neuroimaging genetics in up to 30,000 people from UK Biobank, combined with ancient DNA sequences & comparative genomics, to investigate human brain evolution over a range of timescales. 1/9 pnas.org/doi/10.1073/pn…

UNC_Biology has a job search for a tenure-track Assistant Professor in neurobiology. unc.peopleadmin.com/postings/241191 UNC is a pretty amazing place to do your research, and Chapel Hill is a fantastic place to live, so consider applying and tell your friends!

Cell culture-based GWAS approach identifies lithium-induced pharmacogenomic effects on human neural progenitor proliferation mediated by GNL3. Associated with risk for #bipolardisorder and #schizophrenia, intelligence: elsevier.com/about/press-re… Biological Psychiatry Jason Stein

GWAS in a dish! GWAS of neural progenitor cell proliferation on lithium treatment (n=80) identified a locus on chr 3, a known risk locus for bipolar disorder, schizophrenia and intelligence. Beautiful! sciencedirect.com/science/articl…

🧬A GWAS study from Jason Stein has found a common genetic variation that influences lithium-induced neural progenitor proliferation in cell culture. Nice approach to identifying context-specific effects of psychotropic drugs. 👇sciencedirect.com/science/articl…

Check out our lab's recent work mapping response ca/eQTLs in the context of Wnt stimulation 🪄⚡️.

2 major earthquakes hit Turkey and Syria on Monday affecting many cities where ~15 million people live. The death toll is in the order of thousands and still rising. Please donate and share this fundraiser led by researchers: gofund.me/456c2326

The lightsheet has landed! 🔬🤩🎉 After a lot of preparation and a full week of install, we were thrilled to see some images of distinct nuclei in dense regions of cleared mouse brains and are excited to welcome the Applied Scientific Instrumentation ct-dSPIM to the UNC Neuroscience Microscopy Core!

Super excited to host Bran D Le from Jason Stein next Tuesday at 3pm for the #neurogenomics seminars. Bran will present the lab's excellent recent work linking wnt pathway activation with context specific regulatory QTLs. DM/email for the zoom link

Our recent work together with Jason Stein and Michael Love is published in Genome Biology, to understand cell-type specific causal gene regulatory networks via mediation analysis. To access the full article please click genomebiology.biomedcentral.com/articles/10.11…

Learn how Felix Kyere, Ian Curtin, Jason Stein and colleagues of UNC-Chapel Hill perform whole-brain single-cell imaging and analysis of mouse brains using MRI, tissue clearing, and light-sheet microscopy. Watch on JoVE: hubs.ly/Q01S6wjB0 Jason Stein Felix Kyere @curtin_ian

Excited to share a new preprint on the cross-site reproducibility of human cortical organoids co-led with Elisa Waxman & Deborah French at CHOP and Satoshi Yamashita & Kazue Hashimoto-Torii at Children's National and my PI Jason Stein! biorxiv.org/content/10.110… 1/9

Neocortical Neurogenesis in Development and Evolution edited by WIELAND B. HUTTNER is out doi.org/10.1002/978111…. Superb resource to learn about cortical progenitors; lineages; specification; migration; patterning; cortical regionalisation; folding; disorders; evolution.

We Jason Stein are delighted to present our recent preprint investigating the impact of genetic variants on cell-type-specific post-transcriptional regulation in human brain biorxiv.org/content/10.110…

I am beyond excited to share our new paper on massively parallel reporter assays on schizophrenia-associated variants. This is in collaboration with Jason Stein, Sri Kosuri, Michael Love, Jose Davila Velderrain, Brad Ruzicka, Alan Boyle. 🧵 follows.

📢New from Jason Stein! 📰 #Genetics of cell-type-specific post-transcriptional gene regulation during human neurogenesis cell.com/ajhg/abstract/…

Dr. Jason Stein's lab (Jason Stein) at UNC-Chapel Hill determined the cross-site reproducibility of human cortical #organoid 🧫 (hCO) differentiation using three independent research groups to assay hCOs in multiple differentiation replicates. StemCellReports | bit.ly/4dDxaiJ

The authors of AJHG' latest article identify cell-type-specific genetic regulation of RNA editing and alternative polyadenylation in human neurons and neural progenitor cells. Read the full article here: cell.com/ajhg/abstract/… #ASHG Jason Stein

It’s been a long journey🚢, with about 1 & 1/2 year since posting on bioRxiv and of course even longer since the project started, but our paper has finally been published in Nature Neuroscience 🌠 Congrats Bran D Le @JMValone4 Jason Stein and all co-authors ! nature.com/articles/s4159…

Stimulating Wnt signaling reveals context-dependent genetic effects on gene regulation in primary human neural progenitors Jason Stein Nana Matoba @JMValone4 Bran D Le nature.com/articles/s4159…