Josh Knowles (@joshuawknowles) 's Twitter Profile
Josh Knowles

@joshuawknowles

Assoc. Professor Cardiovascular Medicine, Stanford and Vice Chair, The Family Heart Foundation

ID: 2830498898

calendar_today24-09-2014 21:08:18

2,2K Tweet

2,2K Followers

1,1K Following

Family Heart Foundation (@familyheartfdn) 's Twitter Profile Photo

10 years of #Familyheart24 - so much accomplished - Creates (2) ICD-10 codes / 6k enrolled registry / 230 ambassadors / 650 HCPs on Family Heart Foundation map / consensus statement - and so much more.

10 years of #Familyheart24 - so much accomplished -  
Creates (2) ICD-10 codes / 6k enrolled registry / 230 ambassadors / 650 HCPs on <a href="/FamilyHeartFdn/">Family Heart Foundation</a> map / consensus statement -  and so much more.
Dr. Martha Gulati ♥️🫀❤️‍🩹🇨🇦 (@drmarthagulati) 's Twitter Profile Photo

#FamilyHeartSummit24 Hobbs & Cohen Lab Dr. Helen Hobbs presenting her early work on FH which led her to our French Canadians leading to greater understanding of the genetic mutation that is so common in my country in Quebec 🇨🇦 Further work spread to more diverse popln #FHSummit24

#FamilyHeartSummit24 <a href="/lab_hobbs/">Hobbs & Cohen Lab</a> 
Dr. Helen Hobbs presenting her early work on FH which led her to our French Canadians leading to greater understanding of the genetic mutation that is so common in my country in Quebec 🇨🇦
Further work spread to more diverse popln 
#FHSummit24
Dr. Martha Gulati ♥️🫀❤️‍🩹🇨🇦 (@drmarthagulati) 's Twitter Profile Photo

The patients’ voice always matters. #KnowFH #FHSummit24 Elevated LDL in a child is NOT because of too many cupcakes Family Heart Foundation #FH means checking the whole family #cascadescreening

Dr. Martha Gulati ♥️🫀❤️‍🩹🇨🇦 (@drmarthagulati) 's Twitter Profile Photo

Keith C. Ferdinand, MD, FACC, FAHA, FNLA presenting the @FamilHeartFdn database which shows: 📍 despite dx of #FH: 30% on noTx 📍 61% w/ LDL>70 📍Only 13/100 adequately Tx 📍disparities in management of FH persist: worse control in women, young & Black 📍adherence reflects SDOH & access 🚨WE MUST DO BETTER!

<a href="/kcferdmd/">Keith C. Ferdinand, MD, FACC, FAHA, FNLA</a> presenting the @FamilHeartFdn database which shows:
📍 despite dx of #FH:  30% on noTx 
📍 61% w/ LDL&gt;70
📍Only 13/100 adequately Tx
📍disparities in management of FH persist: worse control in women, young &amp; Black 
📍adherence reflects SDOH &amp; access
🚨WE MUST DO BETTER!
Dr. Martha Gulati ♥️🫀❤️‍🩹🇨🇦 (@drmarthagulati) 's Twitter Profile Photo

Heather M. Johnson, MD, MMM, FAHA, FACC, FASPC presenting on misinformation that affects our #FH patients #FHSummit24 🫀 Misinformation comes from many sources 🫀most especially true for treating LDL/ Cholesterol: we have the evidence and yet the myths appear in our clinics everyday 🫀it is not just BOTs

<a href="/DrHeatherJohn/">Heather M. Johnson, MD, MMM, FAHA, FACC, FASPC</a> presenting on misinformation that affects our #FH patients #FHSummit24
🫀 Misinformation comes from many sources
🫀most especially true for treating LDL/ Cholesterol: we have the evidence and yet the myths appear in our clinics everyday
🫀it is not just BOTs
Dr. Martha Gulati ♥️🫀❤️‍🩹🇨🇦 (@drmarthagulati) 's Twitter Profile Photo

THE Clyde Yancy, MD, MSc discuss if we are making progress in ⤵️ disparities in Healthcare 40 years post Heckler Report: NO WE HAVE NOT! 🫀Ms Heckler-secretary HHS called disparities an affront to 🇺🇸 ideals 🫀Need to ⤵️ bias: Bias is REAL 🫀diversity=Inclusive Excellence #FHSummit24

THE <a href="/NMHheartdoc/">Clyde Yancy, MD, MSc</a> discuss if we are making progress in ⤵️ disparities in Healthcare 40 years post Heckler Report: NO WE HAVE NOT!
🫀Ms Heckler-secretary HHS called disparities an affront to 🇺🇸 ideals
🫀Need to ⤵️ bias: Bias is REAL
🫀diversity=Inclusive Excellence 
#FHSummit24
Dr. Martha Gulati ♥️🫀❤️‍🩹🇨🇦 (@drmarthagulati) 's Twitter Profile Photo

Christie Ballantyne discusses advances on nonstatin Tx at #FHSummit24 ♥️Look at how many LDL⤵️ Tx we have! How far we have come! ♥️ Guidelines & Quality measures necessary to help get patients LDL controlled: optimal LDL goals will help us “get to goal” ♥️ Lp(a) new target now

<a href="/CBallantyneMD/">Christie Ballantyne</a> discusses advances on nonstatin Tx at #FHSummit24 
♥️Look at how many LDL⤵️ Tx we have! How far we have come!
♥️ Guidelines &amp; Quality measures necessary to help get patients LDL controlled: optimal LDL goals will help us “get to goal”
♥️ Lp(a) new target now
Dr. Martha Gulati ♥️🫀❤️‍🩹🇨🇦 (@drmarthagulati) 's Twitter Profile Photo

Amit Khera #FHSummit24 #FINDFH #KnowFH 🧪 FIND FH machine-learning algorithm: validated w/ 87% accuracy in national database 🧪incomplete data affects accuracy 🧪accuracy does not =actionable: we can still reach out to patients identified 🧪Identification is just 1st step

<a href="/dramitkhera/">Amit Khera</a> #FHSummit24
#FINDFH #KnowFH
 🧪 FIND FH machine-learning algorithm: validated w/ 87% accuracy in national database 
🧪incomplete data affects accuracy
🧪accuracy does not =actionable: we can still reach out to patients identified
🧪Identification is just 1st step
Dr. Martha Gulati ♥️🫀❤️‍🩹🇨🇦 (@drmarthagulati) 's Twitter Profile Photo

Fatima Rodriguez #FHSummit24 discusses AI to improve Health Equity 🫀CAC useful but access often limited by 💰 🫀AI to identify Calcification on any chest CT makes it more accessible & more equitable 🫀over half started statin when notified

<a href="/FaRodriguezMD/">Fatima Rodriguez</a> #FHSummit24 discusses AI to improve Health Equity
🫀CAC useful but access often limited by 💰
🫀AI to identify Calcification on any chest CT makes it more accessible &amp; more equitable
🫀over half started statin when notified
Dr. Martha Gulati ♥️🫀❤️‍🩹🇨🇦 (@drmarthagulati) 's Twitter Profile Photo

Dr. Steve Nissen #FHSummit24 #CvPrev #CardioTwitter 🚨🚨🚨We are failing patients🚨🚨🚨 🚨🚨🚨After 3 decades our practice pattern is the same It started in the 1970’s with the Cholesterol Skeptics…& now just stronger despite all the evidence #CVPrev #CardioTwitter

Dr. Steve Nissen #FHSummit24 
#CvPrev #CardioTwitter 
🚨🚨🚨We are failing patients🚨🚨🚨
🚨🚨🚨After 3 decades our practice pattern is the same

It started in the 1970’s with the Cholesterol Skeptics…&amp; now just stronger despite all the evidence 
#CVPrev #CardioTwitter
Fatima Rodriguez (@farodriguezmd) 's Twitter Profile Photo

#FamilyHeartSummit2024 Harpreet Bhatia discussing why Lp(a) is actionable today! Valuable way to refine risk and intensify prevention strategies. Genetics is not destiny.

#FamilyHeartSummit2024 <a href="/hsbhatia/">Harpreet Bhatia</a> discussing why Lp(a) is actionable today! Valuable way to refine risk and intensify prevention strategies. Genetics is not destiny.
Dr. Martha Gulati ♥️🫀❤️‍🩹🇨🇦 (@drmarthagulati) 's Twitter Profile Photo

Michelle O'Donoghue had led key trials on Lp(a) #FHSummit24 📍may require significant ⤵️ in Lp(a) to get benefit but trials are ongoing 📍siRNA class: longer duration & had ⤵️⤵️ >80% of Lp(a)- dose dependent. (95%⤵️ with olpasiran!) 📍1 year off Tx: 40-50%⤵️ Lp(a) with Olp.

<a href="/DrM_ODonoghue/">Michelle O'Donoghue</a> had led key trials on Lp(a)
#FHSummit24
📍may require significant ⤵️ in Lp(a) to get benefit but trials are ongoing
📍siRNA class: longer duration &amp; had ⤵️⤵️ &gt;80% of Lp(a)- dose dependent. (95%⤵️ with olpasiran!)
📍1 year off Tx: 40-50%⤵️ Lp(a) with Olp.
Borge G Nordestgaard (@bnordestgaard) 's Twitter Profile Photo

Elevated remnant cholesterol remains a likely cause of ASCVD in diabetes. Remnant cholesterol-lowering therapies should also lower apoB levels to reduce risk of ASCVD: rdcu.be/dVQJg Risk of ASCVD in diabetes in the Copenhagen General Population Study:

Elevated remnant cholesterol remains a likely cause of ASCVD in diabetes. Remnant cholesterol-lowering therapies should also lower apoB levels to reduce risk of ASCVD:
rdcu.be/dVQJg
Risk of ASCVD in diabetes in the Copenhagen General Population Study:
Joy Wu, MD, PhD (@joyywu) 's Twitter Profile Photo

A tremendous honor to be named the Gerald M. Reaven, MD Professor of Endocrinology Stanford Medicine. The 'Father of Insulin Resistance,' Dr. Reaven was a true legend in Endocrinology. I'll always remember how he welcomed me to Stanford Endocrinology with stories of science and the Division.

A tremendous honor to be named the Gerald M. Reaven, MD Professor of Endocrinology <a href="/StanfordMed/">Stanford Medicine</a>. The 'Father of Insulin Resistance,' Dr. Reaven was a true legend in Endocrinology. I'll always remember how he welcomed me to <a href="/StanfordEndo/">Stanford Endocrinology</a> with stories of science and the Division.