A Molecular Signal Works its Magic from Inside a Straitjacket ucsf.edu/news/2024/09/4…

Dynamic allostery drives autocrine and paracrine TGF-β signaling: Cell cell.com/cell/fulltext/… A new dynamic allostery model of avb8 mediated TGF-b activation, result of a 10+ year collaboration with Steve Nishimura lab at UCSF. Congratulation to MJ, Rob and all co-authors!

Now online! Dynamic allostery drives autocrine and paracrine TGF-β signaling dlvr.it/TDJlBm

Latent-TGF-β has a domain swapped architecture biorxiv.org/cgi/content/sh… #biorxiv_biophys

DiffModeler: large macromolecular structure modeling for cryo-EM maps using a diffusion model Nature Methods • DiffModeler is an automated tool that excels at modeling large protein complexes from cryo-EM maps, particularly at intermediate resolutions (5-10 Å). It offers a

New #CryoSPARC case study! End to end #cryoEM processing of encapsulin and encapsulated ferritin, with a focus on challenges and strategies for handling mixed high-order and non-point-group symmetries. guide.cryosparc.com/processing-dat…

Pleased to introduce DiffModeler, a new tool for str modeling for cryo-EM appeared in Nature Methods this week! Uses diffusion model to emphasize main-chains in maps and fits Alphafold models. Works up to 10-15 A res. nature.com/articles/s4159… Server: em.kiharalab.org

🍂NEW VIDEO🍂 All through Autumn, trees race against time to recycle their chlorophyll--and basically everything else in their leaves. But why go through all this effort? The answers are honestly mind-blowing: rendered in #blender3d using Brady Johnston's #molecularnodes

Architecture and activation of single-pass transmembrane receptor guanylyl cyclase | Nat Struct Mol Biol doi.org/10.1038/s41594…

A drop of water tells the remarkable transformation of Wuzhen (otherwise known as the Water Town), the permanent home of the #WorldInternetConference.

Proud to see the spIsoNet is online now! Hope you enjoy using it!

The Prokaryotic Roots of Eukaryotic Immune Systems annualreviews.org/content/journa…

My hometown!

江南小镇： 小桥流水人家，每一处都像是精心布置的画卷。#大美中国

A novel cryo-EM affinity-grid approach utilizing monodispersed single-particle streptavidin on a lipid monolayer is introduced to improve particle absorption, thereby addressing challenges like preferential angular distribution rdcu.be/d1MNM eBIC Beamline STRUBIOxford

The ChimeraX 1.10 release candidate and daily builds can predict small complexes of proteins, nucleic acids and small molecules using Boltz on your Mac, Windows or Linux computer. rbvi.ucsf.edu/chimerax/data/…