Great article about technological advances for studying 3D genome organization nature. A pleasure to host @amberldance in our lab and talk with her for this piece. Particularly enjoyed the lede featuring SHARP-Y (created by Jimmy K. Guo oliviaettlin )!

Really proud of Jimmy K. Guo for giving an awesome talk on his graduate work at CSHL Regulatory RNA meeting - his first at a major meeting! #cshlregRNA

A Comment from Jimmy K. Guo and Mitch Guttman highlights recent method developments in studying RNA-protein interactions and discusses the future opportunities in and challenges of exploring ncRNA functions. nature.com/articles/s4159…

Excited to share our Comment now out in Nature Methods! Mitch Guttman and I discuss the massive regulatory potential for ncRNAs and the technical challenges faced by the field in bridging the gap between this potential and functional relevance. nature.com/articles/s4159…

In our new pre-print, we demonstrate that 3D genome organization around nuclear speckles controls the efficiency of mRNA splicing. Check out my thesis work Caltech in this thread by Mitch Guttman! 4DNucleome #Genomics

Excited to share the first part of my PhD work! Into the SPIDR-verse! This massively multiplexed CLIP method will take your research to a multiverse of possibilities 🕷️🕸️

Gene expression involves thousands of proteins that bind DNA, yet comprehensively mapping these is challenging. We developed ChIP-DIP – a method for simultaneous, genome-wide mapping of hundreds of DNA-protein interactions in a single experiment. biorxiv.org/content/10.110…

Online Now: Denaturing purifications demonstrate that PRC2 and other widely reported chromatin proteins do not appear to bind directly to RNA in vivo dlvr.it/T33rxh

1/ Is RNA essential for PRC2 chromatin occupancy? Here we refute evidence that was previously used to support this idea. Work by Evan Healy and Qi Zhang from the Chen Davidovich, Monash Biomedicine Discovery Institute, EMBL Australia. cell.com/cell-reports/f…

What is the role of RNA in PRC2 chromatin association? Pleased to share that Alex Hall Hickman’s work showing that the RNA bridge model is based on an experimental artefact has now been published Cell Reports cell.com/cell-reports/f…

Excited to share a new preprint! (1)🔬The nucleolus is the most prominent nuclear condensate, with a fascinating multilayered liquid-like structure, and is the site of ribosome biogenesis. But how does this multiphase architecture form and function? biorxiv.org/content/10.110…

A report made counterintuitive claims that PRC2 binds → more RNA than PTBP1 & hnRNPU → RNAs that do not exist in the cell We found a simple explanation: the authors ignore most RNA in the sample, leading to inflated background & misleading conclusions. biorxiv.org/content/10.110…

Gene regulation involves thousands of proteins that bind DNA, yet comprehensively mapping these is challenging. Our paper in Nature Genetics describes ChIP-DIP, a method for genome-wide mapping of hundreds of DNA-protein interactions in a single experiment. nature.com/articles/s4158…

Isogenic comparison of Airn and Xist reveals core principles of Polycomb recruitment by lncRNAs dlvr.it/TJjsx8

Happy to share our new SPIDR method for mapping RBPs at scale out in Cell!