#OriginalResearch simpub #CircACC23: The HOST-IDEA RCT showed DAPT duration of 3-6mo was non-inferior to 12mo for net adverse clinical events in patients undergoing PCI with 3rd-gen DES @drlsj ahajrnls.org/3Yo1gyd

Oral #PCSK9 inhibition? Safe, tolerated and effective at reduction of #LDL cholesterol. Phase 2b announced by Christie Ballantyne jacc.org/doi/10.1016/j.… JACC Journals American College of Cardiology #ACC23

Efficacy and safety of the oral PCSK9 inhibitor MK-0616: a phase 2b randomized controlled trial | Journal of the American College of Cardiology Exciting data just presented today looking forwards to phase 3 program ⁦Prof Alberico L. Catapano⁩ jacc.org/doi/10.1016/j.…

Wow! New era of poc trops on the horizon? academic.oup.com/ehjdh/advance-…

#CathLabHack: Sterile maintenance of #PercloseSutures around #IndwellingLargeBoreSheath w constant pull on nonlocking suture to⬇️#Oozing #StopcockBluntNeedleCombo technique: youtu.be/tVdj7cqTnW8 #CutSheathSideport technique youtu.be/tz-dLQ2CO9I Erik Rafflenbeul PCRonline 🫀

Interesting findings reported from 5-yr data of Define-flair showing increased mortality seen in iFR compared with FFR. Differs from 5yr outcome of iFR-SWEDEHEART.

Dietary Effects on Monocyte Phenotypes in Subjects With Hypertriglyceridemia and Metabolic Syndrome | JACC: Basic to Translational Science. Clinical study ⁦Huaizhu Wu⁩ ⁦BCM_CVRI⁩ Impact of high saturated fat diet on monocytes jacc.org/doi/10.1016/j.…

Nearly 1 in 5 US adults with T2D but without symptoms of CVD have a clinically meaningful elevation of a marker of cardiac damage — namely, high sensitivity cardiac troponin T — based on data. ms.spr.ly/6012g5O5G

Multiple failed #Perclose post Impella. Heavily calcified CFA! Two 8F #Angioseals did the trick! This is how to do it - Place two wires through the 14F sheath - Remove the sheath and place 8F sheath on one wire and Angioseal using the other - Then Angioseal using the second

Our study on association comparing IL6 and IL18 in older adults. Both associated with cvd risk but IL6 with stronger association which was independent of hsCRP, NTproBNP, and hs-cTn #inflammaging #aric BCM Cardiology BCM_CVRI

We prev showed that an IL6R coding variant led to greater reduction in CAD risk for humans w CHIP vs w/o. ahajournals.org/doi/10.1161/CI… Circulation Beautiful new work now validates this concept in an experimental atherogenic Tet2 chimeric murine model nature.com/articles/s4416… Nature Cardiovascular Research

A mind-blowing paper has come out today in nature In 2016, JC Venter Institute scientists trimmed a bacterial genome to its barest minimum required for life to synthesize what they called a "minimal genome" (science.org/doi/10.1126/sc…). Today, a group of scientists from

Adrenomedullin plays a key role in vascular homeostasis in #HF, and is also a substrate for neprilysin. In #PROVEHF and #PARAMOUNT we analyzed changes in MR-proADM during treatment with #ARNI in assoc w changes in echo and health status 1/7 🧵 onlinelibrary.wiley.com/doi/10.1002/ej…

Our 📝 on the effectiveness of PFO closure in practice is online👇 In typical device Intv research, results are + in OBS studies but - in RCT Here is the opposite, PFO closure was NOT associated with less recurrent strokes or SE compared w medical Rx in US clinical practice

High-Sensitivity Cardiac Troponins I and T and Cardiovascular Outcomes: Findings from the Systolic Blood Pressure Intervention Trial (SPRINT) academic.oup.com/clinchem/artic… Xiaoming Jia nambi seshadri BCM Cardiology BCM_CVRI Nicholas Mills @JJheart_doc

#OriginalResearch: Proteogenomic data integration reveals CXCL10 as a potentially downstream causal mediator for IL-6 signaling on atherosclerosis #AHAJournals ahajrnls.org/47une7c

Very interesting paper - Rethinking False Positive Exercise Electrocardiographic Stress Tests by Assessing Coronary Microvascular Function | Journal of the American College of Cardiology jacc.org/doi/10.1016/j.…

3. Very Low LDL-C Concentrations Regardless of therapy LDL-C concentrations of < 1.8 mmol/l or 70 mg/dl Resulted in plaque regresion. But the amount of plaque regression increased the lower these levels were taken.

Impact of Elevated Gradients After Transcatheter Aortic Valve Implantation for Degenerated Surgical Aortic Valve Bioprostheses ahajournals.org/doi/10.1161/CI… Special thanks to R. Yazan Kherallah and all others for bringing this project over the finish line!

Thrilled to collaborate on this paper on "Early Onset Athero..." with a stellar group led by Idine Mousavi and Xiaoming Jia and co! 🌟This review and our proposed #cvPrev strategies out now in European Society of Cardiology Journals 👇 doi.org/10.1093/eurjpc… Erin D. Michos, M.D. Christie Ballantyne Salim Virani