1/ Let's differentiate pyogenic from amebic liver abscess in a #Tweetorial today. We will examine DDx, risk factors, microbiology, clinical features, diagnostics, and treatment. This came from my most recent morning report. #IDTwitter #LiverTwitter #MedEd

Oral Therapy for Bacteremia and Endocarditis Noah Wald-Dickler, M.D. giving talk for Brad Spellberg "No, you're not in the wrong room, and Brad Spellberg did not get younger and more handsome." #IDWeek2022 #IDTwitter

So excited to share an #IDTwitter collaborative article! Together with Nico Cortes-Penfield MD FACP FIDSA 🦴💊 Todd C. Lee Steven Tong Emily McDonald @JGPharmD and Irani Thevarajan, we did a systematic review & meta-analysis on gent & rifampin in Staph prosthetic valve endocarditis! academic.oup.com/ofid/advance-a…

OFID tonight is 🔥🔥 The existing clinical data do not suggest a benefit of either adjunctive gentamicin or rifampin in staphylococcal PVE Authors suggest recommendations for gentamicin & rifampin in PVE be downgraded & they primarily be used within the context of clinical trials

Draadje / slurfje 🧵🐘 over PREP. Wat is Prep, hoe werkt het, waarom zouden we het voorschrijven en waarom zouden we er ook als huisarts een rol in nemen ? @DrZemouri vul je aan als je wilt ? nos.nl/l/2452710

#DoxyPEP prevented STIs in gay men, but Jenell Stewart reports this was not the case for cisgender women. May be due to differing drug concentrations in vaginal/cervical vs rectal tissue or low adherence. We’ve seen something similar with TDF/FTC PrEP for women. #CROI2023

#CROI2023: Treatment for tuberculosis, a leading cause of death worldwide, typically involves 6 months of continuous therapy. In the TRUNCATE-TB trial, a strategy involving shorter initial treatment was noninferior to standard treatment. nej.md/3XsQB4H

Happy to share my publication in CID, in which we show that the degree of pyuria can help to distinguish UTI from ASB in older women academic.oup.com/cid/advance-ar…

Do INSTI drive CVD? According to @HivSwiss, in 1st line ART, no!! Unadjusted higher risk CVD events disappeared when adj for factors incl education, FH (too often ignored!) & ABC or TAF use. Great work, suppressed switch analysis needed #CROI2023 WITH PERMISSION

Some #croid2023 Day 1 (Feb 20) highlights. Let's start with the doxy for STI preventions studies. #119: DOXYVAC: AN OPEN-LABEL RANDOMIZED TRIAL TO PREVENT STIs IN MSM ON PrEP. Doxy 200 mg PEP ⬇️ syphilis, chlamydia, and GC, as did the men b vaccine for GC. 1/x

Persistent low level viraemia pre-switch to IM-CAB/RPV more likely to have same post-switch. At least one +VL in year pre-switch = more likely to have a detectable VL post-switch #CROI2023 @tristanjbarber Paul Sax

Monica Gandhi MD, MPH IM-CAB/RPV in ppl not necessarily virally suppressed at start. No RAMs. 133 ppl, 57 not VS. All VS ppl stayed VS, 2/57 not VS had early VF = 1.5% overall (but 3.5% of not VS at baseline group). 2 with VF had minor RAMs since disallowed in the programme #CROI2023

#518 HIGH VIROLOGIC SUPPRESSION RATES ON LONG-ACTING ART IN A SAFETY-NET CLINIC POPULATION From UCSF Ward 86: CAB/RPV in 133 PWH very much NOT the usual candidates. 57 with viremia, suppression in 55(!); 2 with failure and resistance. Need this success replicated elsewhere! x/18

Interessant concept 2x per jaar injectie/infusie - nog veel over te leren #croi2023

Memorabel moment als dit advies door kabinet wordt overgenomen!! #OMT: grootschalig testen op corona niet meer nodig, ziekte 'hoort erbij' /via NOS nos.nl/l/2465003

Ben jij tussen de 18 en 27 jaar en nog niet gevaccineerd tegen #HPV? Dan kan je zaterdag 4 maart zonder afspraak een prik halen. Het is dan HPV Awareness Day. 45 GGD-priklocaties openen de deuren zodat je zonder afspraak de HPV-vaccinatie kan halen. ➡️ rijksvaccinatieprogramma.nl/form/hpv-prik-…

Attractive option? 🆕️⚡️ JAC-AMR Intravesical aminoglycoside instillations as prophylaxis for recurrent urinary tract infection: patient satisfaction, long-term safety and efficacy #IDTwitter academic.oup.com/jacamr/article…

Indrukwekkend verhaal in NRC vanmorgen: Zo belandt fout Braziliaans rundvlees toch op een Nederlands bord via NRC nrc.nl/nieuws/2023/06…

#CROI2024 single-dose HPV vaccine schedule has been adopted by 37 countries globally - driven by evidence, not just cost! COVID showed us that global vaccination IS possible! HPV screening is the most effective tool to prevent HSIL & cervical cancer. Brilliant talk, thank you!

3 tiebreaks 💪🏽 Libéma Open🎾 Tallon Griekspoor